Head of Induced Proximity Platform (IPP)

Thousand Oaks, California
Commensurate with experience
August 09 2019
Position Type
Full Time
Organization Type

Head of Induced Proximity Platform (IPP)

Amgen seeks a highly motivated individual to be the founding Head of our Induced Proximity Platform (IPP). IPP builds on the demonstrated potential of bispecific agents that serve as molecular bridges to link together two proteins and/or cells to treat disease across multiple therapeutic areas. Examples of successful bispecifics across industry include the approved agents lenalidomide, sirolimus, cyclosporin, blinatumomab, and emicizumab, as well as the emerging PROTACs.

We seek to develop a small molecule-based Induced Proximity Platform to enable its use as a general approach to modulate intractable targets in diseases with high unmet need, with initial emphasis on the emerging PROTAC modality. Development of this platform will be enabled by Amgen's recent acquisition of Nuevolution, a leading innovator of DNA-Encoded Library (DEL) technology. You will lead a group of PhD and non-PhD level biologists and chemists to develop novel therapies for paradigm changing multi-specific drugs of the future.

The Head of IPP will report to the Senior Vice President for Global Research, and will be based in Thousand Oaks, Ca.

Primary Responsibilities:

  • Build on the success of Amgen's bi-specific modality approach to expand and accelerate development of the IPP, including PROTACs and other induced proximity technologies
  • Establish a comprehensive knowledge base of current and emerging relevant science and technology
  • Define a vision for the platform and implement a long-term scientific/technical strategy
  • Drive excellence in recruiting and growing intellectual human capital to build a hardworking and diverse organization that will deliver the next generation of Amgen's therapeutics
  • Foster and drive culture and processes to ensure open, timely, and relevant communication within/across organizations
  • Advance personal and organizational knowledge of the IPP to be a champion for Induced Proximity science and technology internally and externally (industrial & academic)
  • Ensure organizational alignment across Global Research (Therapeutic Areas, Therapeutic Discovery, Preclinical Development), Global Development and Process Development through active management of key relationships as well as resources with Corporate and R&D priorities
  • Outline and implement medium and long-range strategic business plans to meet current and future scientific needs, business requirements and a workforce management plan
  • Management of budget and prioritization of resources

Basic Qualifications:

  • Doctorate degree and 6 years of biological research experience OR
  • Master's degree and 10 years of biological research experience OR
  • Bachelor's degree and 12 years of biological research experience AND
  • 6 years of managerial experience directly managing people and/or leadership experience leading teams, projects, programs or directing the allocation of resources

Preferred Qualifications:

  • PhD or MD degree plus 10 years' experience in biological research beyond postdoctoral studies
  • Recognized thought leader with deep expertise and proven record of research in biochemistry, structural biology, genetics, and/or cellular and molecular biology
  • Familiarity with drug discovery technologies
  • Possesses personal leadership qualities that inspire trust, respect, credibility and confidence of peers and colleagues and takes the organization to a higher level
  • Ability to create, grow and develop high performing teams that deliver outstanding business results
  • Success in an environment that drives innovation, where individuals can think creatively and take calculated risks
  • Experience building and leading teams, and operating within a complex, multi-site matrixed organization

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.