Postdoctoral Fellowship in Neurodegeneration
Postdoctoral Fellowship in Neurodegenerative Diseases:
Mechanisms, Biomarkers and Novel Therapeutics
Job Description: NIH funded postdoctoral positions are available in the laboratory of Benjamin Wolozin to study the molecular basis of neurodegenerative disease. The laboratory investigates the role of RNA binding proteins in the pathophysiology of neurodegenerative diseases, including Alzheimer disease, amyotrophic lateral sclerosis (ALS) and Parkinson disease. In collaboration with Andrew Emili, we are also extending our work to include characterization of proteomic networks in neurodegenerative disease. The laboratory also has funded projects developing human organoid models of neurodegenerative disease, and in biomedical engineering, creating synthetic biology tools to treat neurodegenerative disease.
Current studies characterize the protein interaction and RNA interaction networks of RNA granules and pathological complexes (e.g., tau, TIA1, TDP-43). An important goal is to understand how the complexes change with disease, identify which are the crucial modulators of each type of complex, and identify methods of intervention to normalize the disease-related changes of these complexes.
Upon joining my laboratory, the postdoctoral candidate will focus on studies of neurodegenerative disease, ranging from in vitro studies of liquid-liquid phase separation, to analysis of splicing and translation, to investigation of animal or human (iPSC/organoid) models of disease. Approaches utilize live imaging, proteomics, systems biology, viruses and synthetic biology. Recent studies demonstrate that reducing the RNA binding protein TIA1 delays progression in a mouse model of tauopathy (Apicco, et al, Nature Neuro., 2018, 21(1):72-80, PMID: 29273772; Jiang et al, Acta Neuropath. 2019, 137(2):259-77. PMID 30465259).
- Animal models of tauopathy and ALS: Mechanisms
- RNA metabolism: RNA binding proteins, proteomics, RNA translation, RNAseq, eCLIP, bacTRAP
- Human iPSCs/organoids and brain: biomarkers and therapeutic approaches
Desired Skills: Any of the skills below would be helpful for this position.
- Gene delivery, viruses, over-expression, knockdown, CRISPR
- Biochemistry and protein aggregation
- Immunohistochemistry, Immunoprecipitation, immunoblotting
- Molecular Neuropathology
- Systems Biology
- Neuronal culture: primary neuron culture, iPSCs and cell lines
- Live cell imaging and Super-resolution imaging
About the employer: The laboratory is well funded and positions are available immediately. Boston University School of Medicine is located in the heart of one of the world’s most vibrant biotechnology communities. The laboratory is a moderate sized lab (~10 people), with 2200 square feet of space, with all necessary resources.
Highest priority will be given to candidates who are about to finish their Ph.D., or within 1 year of finishing their Ph.D. (i.e., early postdocs). For more information, visit the Wolozin Lab website: http://www.bumc.bu.edu/busm-pm/research/laboratories/wolozinlab/