Fellow - PhD - Piliponsky Lab

Location
Seattle, Washington State
Salary
DOE
Posted
July 31 2019
Discipline
Health Sciences
Position Type
Full Time
Organization Type
Healthcare/Hospital

Fellow - PhD - Piliponsky Lab

A post-doctoral position is available within the laboratory of Dr. Adrian Piliponsky at Seattle Children’s Research Institute, Department of Pediatrics, University of Washington (Seattle, WA). 

Research in Dr. Piliponsky’s lab is focused on the regulation of the innate immune response to bacterial infections; with special interest on mast cells and basophils. Please refer to our recent publications on basophils and innate immunity in sepsis (Piliponsky et al. Nature Immunology 2019, PMID 30664762) and mast cells and innate immunity during infections with Group B Streptococcus (Gendrin C et al. J Allergy Clinical Immunology 2018, PMID 28916188).  

Piliponsky lab uses biochemical and molecular biology approaches in combination with mass spectrometry to validate targets of mast cell proteases. They employ mast cell and basophil-deficient mice, mice deficient in mast cell specific proteases, and immune reconstitution of mice with modified hematopoietic stem cells to investigate the contribution of these targets and their down-regulation by mast cell proteases to inflammation. 

The post-doctoral hired for the position will use an array of cellular and molecular approaches (ELISA, cell isolation, flow cytometry, histology, RNAseq and transcriptome analysis, qPCR, bacterial propagation; as well as, animal models of infection). They will also be expected to formulate, execute, and communicate research projects. 

Please include at least one publication on your resume. 

Also be prepared to copy/paste a cover letter briefly describing your research accomplishments, interests and career goals.


Requirements

Requirements include a recent PhD and/or MD in Immunology or other cell biology- related fields (preferably including immunology training). PhDs graduated within two years are particularly encouraged to apply.

Successful candidates should be highly motivated with an outstanding publication record (at least one first-author research paper published in peer-reviewed international journal) and work ethic. Candidates are required to have a strong research background in cellular immunology, biochemistry, and mouse models of bacterial infections; as well as, excellent written and oral communication skills in English.