About the Simeone Diane, MD Laboratory: Pancreatic cancer detection, etiology, and treatment.
Pancreatic ductal adenocarcinoma (PDA) is a highly fatal malignancy which is projected to become the second leading cause of cancer-related deaths in the Unites States in 2030 (Rahib et al., 2014; Siegel et al., 2018). PDA is characterized by delayed onset of symptoms, early metastasis, and frequent occurrence of resistance to clinically administered therapies. The main overarching goal of the Simeone laboratory is to identify mechanisms and cellular pathways that regulate pancreatic cancer initiation and progression, as well as developing novel more effective therapeutics.
We are focusing our efforts in the following main areas:
- Introducing novel therapeutic approaches for DDR gene mutant pancreatic Cancer
- The role of the pancreas immune microenvironment in disease progression.
- The role of ATDC in pancreatic cancer development and progression
Our laboratory is looking to hire a postdoctoral fellow with a strong background in the fields of molecular biology, cell biology, cancer biology, or immunology.
Dr. Simeone is an internationally renowned physician-scientist and currently the director of the NYU Pancreatic Cancer Center. Our lab, established within the NYU Pancreatic Cancer Center uses multiple advanced genomic technologies to study the mechanisms of disease progression and to understand the biology underlying this process to define new targets for therapy. The laboratory currently employs many different in vitro and in vivo approaches, including patient-derived organoids and tumor xenografts, as well as genetically engineered mouse models to characterize and validate new targets and therapeutic strategies. We seek individuals with a strong background in immunology, molecular biology, and biochemistry to work on projects interrogating the role of microenvironment and immune system in pancreatic cancer etiology and response to therapy. We have an expanding research program focusing on different molecular subtypes of pancreatic cancer, including HR-deficient PDA. The successful candidate will be a driven, creative, team-oriented individual with a passion for translating key cancer biologic findings towards the clinical setting.
About the Postdoctoral Affairs Program at NYU Langone Health:
In addition to world-class research facilities, the laboratory benefits from the collaborative and vibrant scientific environment of NYU Langone medical center and the outstanding medical school infrastructure. NYULMC also has a robust career development program led by our Office of Postdoctoral Affairs. One of only 17 schools to receive an NIH BEST (Broadening Experiences in Scientific Training), the Office of Postdoctoral Affairs offers over 30 courses and workshops on career planning, communication skills, negotiating, and conflict management, as well as career-specific training for careers in academia, pharma/biotech, science policy, medical communications, and many more. Additional information can be found at www.med.nyu.edu/postdoc.
Requirements: Candidates should have a broad experience in cell biology, biochemistry, and molecular biology. Experience with animal models (xenograft or GEMM) and multicolor flow cytometry analysis is valued positively. A background in DNA damage signaling or immunology is desirable. Priority will be given to individuals with an outstanding publication record from their prior graduate and postgraduate training and/or existing extramural funding. We welcome applications from both recent Ph.D. recipients and individuals seeking additional postdoctoral training. Proficiency in English is required.
To apply: submit a detailed CV, a brief statement of research interests with a description of previous research experience, and contact information (email addresses and telephone numbers) for three references to Dr. Daniel Diolaitiat Daniel.Diolaiti@NYUlangone.org. Consideration of submitted applications will start immediately and will continue until positions are filled.
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