Postdoctoral Fellow - Computational Biology, Biostatistics and Bioinformatics

Location
Monrovia, California
Salary
Competitive
Posted
July 26 2019
Ref
10001970
Position Type
Full Time
Organization Type
Healthcare/Hospital
About City of Hope




City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

We are seeking a talented and motivated Postdoctoral Fellow to become a part of the multidisciplinary research team headed by Dr. Ajay Goel, who recently relocated to the City of Hope. His research is highly focused on understanding the interplay between genetic and epigenetic alterations in colorectal, pancreatic, gastric and esophageal cancers. One of the primary translational research goals is to develop novel diagnostic, prognostic, and predictive biomarkers for various gastrointestinal cancers, as well as study immune regulation and identify novel therapeutic targets (e.g. targeted therapies, immune checkpoint inhibitors) for various GI malignancies. Our multidisciplinary research group comprises of basic biologists, gastroenterologists, surgeons, oncologists and bioinformaticians, undertaking a number of collaborative projects involving large international consortia.




The projects will involve any/all of the following research focuses:
  • Exploration of cell-free DNA-based, liquid biopsy biomarkers for the early-detection of gastrointestinal cancers (including colorectal, pancreatic, gastric, liver and esophageal).
  • Establish innovative methodologies involving non-coding RNAs-based biomarkers for the earlier diagnosis, prognosis and predictive responses to chemotherapy in gastrointestinal neoplasia.
  • Understanding the genetic basis of early-onset and familial/hereditary colorectal cancers
  • Molecular mechanisms of cancer pathogenesis, the role of stem cells in the context of chemo resistance chemo-sensitization in cancer cells.
  • Gut microbiome and its influence in gastrointestinal cancers

The position is largely computational and biostatistical, but involves substantial collaboration with wet-lab researchers providing data and is focused on fundamental biology. This interdisciplinary position offers opportunities to address important questions in computational biology and cancer genomics with first access to large novel data sets from various genomic/epigenomic platforms.

Basic education, experience and skills required for consideration:
  • PhD in bioinformatics, computer science, data science, mathematics, statistics, physics or equivalent
  • Demonstrated experience analyzing next generation sequencing data in cancer, particularly whole genome, exome, methylome, small RNA and total transcriptome sequencing analysis including:
    • Differential expression analysis, SNV calling, indel calling, rearrangement/translocation calling, CNV identification and analysis.
    • MiRNA and other small RNA sequencing analysis
    • EPIC array data
    • circRNA profiling
  • A good knowledge and understanding of cancer biology
  • Passion for science and reproducible scientific work
  • Proficient in spoken and written English
  • Being comfortable in interacting with colleagues in an interdisciplinary setting


Preferred education, experience and skills:
  • Prior experience as a bioinformatician/biostatistician/computational biologist with a deep appreciation of biological phenomena or, alternatively, experimentalists with a solid background in bioinformatics/computational biology analysis of transcriptomic and genomic data with regard to detection of differentially expressed genes, noncoding RNAs, DNA methylation and differential processing profiles.

Additional information:
  • Curriculum Vitae and coordinates of three scientific mentors
  • A cover letter highlighting your research interests, a brief statement explaining how your past research ties in with the goals of our laboratory, and future career plans.



City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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