Postdoctoral Fellow in Precision Discovery and Molecular Pathogenesis of Lymphoma
Applications are invited for a post-doctoral fellowship position in the Precision Discovery Program in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania.
The desired candidate will be a highly motivated individual with demonstrated track-record of productivity. The position will focus on studying molecular mechanisms and pathogenesis of lymphoma initiation and progression. Studies will include interrogation of major pathways of cancer, ubiquitin-mediated proteolysis, and cell cycle pathway deregulation. The candidate will have opportunities to combine genetic approaches with mass spectrometry-driven proteomic analyses for the investigation of protein-protein interactions that underlie lymphoma pathogenesis. Studies will also entail RNA interference and pharmacologic inhibition of involved pathways in vitro and hypothesis testing and phenotypic characterization of unique in vivo transgenic models. Accordingly, the position will require experience with all aspects of DNA-construct design, production, site-directed mutagenesis, transduction of primary and cultured cells. Deep skills in immunology and strong mouse genetics skills would be well-suited for this position. The techniques to be employed include: cell culture, transfection with plasmid constructs, analysis of cellular proteins using immunoprecipitation, immunophenotypic studies, SDS-PAGE and Western blotting, analysis of gene expression using Northern analysis and quantitative RT-PCR, cell cycle analysis using flow cytometry.
The candidate is expected to be an independent thinker and able to trouble-shoot technical difficulties, maintain adequate records and clearly communicate scientific results and interpretation verbally, and in writing to the principal investigator and scientific community. The successful candidate would be integrated in a vibrant and interactive community including immunologists, cancer and computational biologists, hematopathologists, mass spectrometrists, and clinicians at the University of Pennsylvania.
A Ph.D., and/or M.D. degree with a strong background in biochemistry, molecular and cellular biology is required. Significant experience with mouse genetics techniques will be advantageous. Excellent interpersonal skills to function optimally in the project team and to cooperate with collaborators will be important. The position is available immediately, but later starting dates are possible.
Appointment: 12 months, and depending on performance, opportunity for annual renewals up to 36 months. 100% research commitment
Salary: Commensurate with experience and qualifications. Continuation of position is subject to the needs of the department, performance, and availability of funding.
Please email resumes and three references to:
Kojo S. J. Elenitoba-Johnson, M.D., Professor
Department of Pathology and Laboratory Medicine
University of Pennsylvania