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Postdoctoral Scholar in Cancer Biology

Employer
University of California, San Francisco (UCSF)
Location
San Francisco, California
Salary
Payscale is determined by the University and existing union contract
Closing date
Sep 12, 2019

Postdoctoral Scholar in Cancer Biology

Postdoctoral position is available now at the UCSF Helen Diller Family Comprehensive Cancer Center at the mission bay campus for an outstanding candidate interested in cancer biology or translational cancer research. Our laboratory is interested in tyrosine kinase oncogenes in epithelial cancers, with a focus on the HER and Src family of tyrosine kinase oncogenes. A position is currently open to study Src signaling, although ambitious candidates may pursue a broader scope of work within our research program.

Despite an abundance of evidence regarding the transforming potential of Src kinases, their role in human cancers remains unproven and response to Src inhibitors unimpressive. This has led us to re-examine how Src kinases function in normal physiology and in cancer pathogenesis. New evidence, developed in our lab, has revealed that Src kinases have functions more complex than previously thought, and their engagement in human cancer may not follow the same paradigms as other kinase oncogenes. This work builds on a substantial body of data and model systems and reagents already established in our lab.

Our work encompasses a wide range of in vitro and in vivo experimental techniques including protein biochemistry and signaling, gene expression, gene knockdown and knockout models, mouse xenograft and genetic models, and interrogation of clinical samples. We are also involved in several drug discovery efforts to test novel interventional strategies. UCSF is a highly collaborative environment and our laboratory is involved in collaborations with multiple other research programs within the scientific community including programs in systems biology, small molecule discovery, chemistry and chemical biology, and structural biology. More information available at www.lab.moasser.com. Highly motivated candidates with an MD or PhD and a strong background in molecular and cellular biology please send CV to Mark M. Moasser, MD at mark.moasser@ucsf.edu

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