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Principal Research Associate, Analytical Development

Employer
Moderna
Location
Cambridge, MA
Salary
Competitive
Closing date
Dec 6, 2019

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Job Details

The Role:

Moderna is seeking a highly skilled, talented and motivated in vitro analyst for a position based at their Cambridge, MA site. The individual will participate in the development and performance of cellular and biochemical potency assays to support advancement of Moderna's mRNA clinical development candidates.

Here's What You'll Do:
  • Development and performance of in vitro potency assays (e.g. ELISA, FACS, luminescence, functional activity) using cultured and primary mammalian cells to support product development
  • Transfer of potency assays to CRO/QC laboratory for qualification and validation, for release and stability testing under GMP
  • Standard mammalian cell culture support including maintaining and plating of cell lines
  • General laboratory assistance including lab equipment maintenance, preparation of reagents, and the ordering and receiving of lab supplies
  • Closely collaborate with members of the In Vitro Biology, Technical Development and Quality Control teams, and broadly with R&D departments throughout the company
  • Accountable for experiment design, success and results delivery
  • Record and communicate findings
  • Presentation of results at internal meetings


Here's What You'll Bring to the Table:

Minimum Qualifications
  • BS with 5-8 years of industry experience, or MS with 2-5 years of industry experience (Immunology, Cell Biology, or related science), developing and performing cellular and/or immunological assays
  • Significant hands on experience with mammalian cell culture and the utilization of cell-based assays to examine the activity of protein targets
  • Strong immunology background
  • Experience in ligand binding assay development and performance (ELISA, MSD, bioplex, other)
  • Experience with functional cell-based assay development (e.g. cytotoxicity, proliferation, HTRF or other pathway signaling assays, cytokine release, other) and sample testing
  • Excellent interpersonal, organizational, and collaborative skills, attentive to detail, and the ability to work independently and effectively in a highly dynamic environment

Preferred Qualifications
  • Experience in a GxP environment
  • Familiarity with the regulatory landscape and government agency guidance for potency assay development, qualification and validation
  • Familiarity with nucleic acid therapeutic characterization
  • Ability to multi-task to meet aggressive timelines and development goals


Here's What We'll Bring to the Table:
  • Daily on-site catered lunches
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass
  • Free annual corporate membership to Bluebikes
  • Highly competitive healthcare coverage including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • 16 weeks of 100% paid parental leave for all new parents
  • 16 weeks 100% paid family caregiver leave
  • 20 weeks 100% paid medical leave
  • Adoption assistance and discounts to local childcare centers, as well as access to care.com
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays (includes 2 floating holidays)


Why join Moderna

At Moderna, we believe messenger RNA, or mRNA, is the "software of life." Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. Given its essential role, we believe mRNA could be used to create a new category of medicines with significant potential to improve the lives of patients.

Headquartered in Cambridge, Mass., Moderna currently has strategic alliances for development programs with AstraZeneca, Plc. and Merck, Inc., as well as the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense; and the Biomedical Advanced Research and Development Authority (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS). Moderna has been ranked in the top ten of Science's list of top biopharma industry employers for the past four years. To learn more, visit www.modernatx.com .

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

#LI-AG1

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Company

Moderna is a clinical stage pioneer of messenger RNA (mRNA) Therapeutics™, an entirely new in vivo drug technology that directs the body’s cells to produces human proteins, antibodies and novel protein constructs, which are in turn secreted or active intracellularly. Founded in 2011, we are headquartered in Cambridge, Mass. 

Our Team and Mission

We currently have over 500 team members, an exceptional group of scientists and industry professionals who are wholly committed to advancing Moderna’s mission:  deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

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