Institute Associate Scientist II - Protein Science

Houston, Texas
July 15 2019
Organization Type

Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently – all under the same roof.

The Therapeutics Discovery Division is built around four platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium.

The ORBIT platform drives the development of novel biologic therapies for Therapeutics Discovery. Our team works with MD Anderson clinicians and researchers to identify novel cancer targets and develop monoclonal antibodies that we can advance for new therapeutic options. Our model unites the advantages of a biotech-like environment with the science and clinical care for which MD Anderson is known. Through our integrated platform, we work with greater agility to avoid the traditional barriers that hamper monoclonal antibody development, and already we have seen our discoveries advance into clinical trials to improve the lives of patients.

The ideal applicant will be an established research associate with experience on protein characterization and/or molecular biology. The position requires a highly self-motivated individual, with outstanding organizational skills, capable to effectively present results and conclusions to co-workers, collaborators and manager. Capability to work in a team based setting where meeting team goals defines success is essential. Preference will be given to candidates with experience in monoclonal antibody biophysical and biochemical characterization and antibody-antigen interaction analysis, molecular biology.


1. Under minimal supervision, conduct laboratory experiments on antibody expression and characterization to support antibody leads discovery for therapeutic drug discovery projects.

2. Execute immunoassay manipulations in various formats.

3. Conduct protein characterization including HPLC, UV SDS-PAGE, Western blotting and LC-MS assays.

4. Execute molecular cloning, cell culture, protein expression and purification.


Ex Execute antibody/antigen binding assay using Octet and antibody drug conjugate characterization.

6. Participate in integrated drug discovery research activities by engaging in interaction with scientists of different disciplines.

7. Employ safe lab practices.

8. Maintain research records and laboratory notes.

Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field. Education

Preferred: Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology or related field.


Required: One year of relevant research experience in lab. With preferred degree, no required experience.

Preferred: Experience in molecular cloning, protein biophysical and biochemical characterization and high throughput cell-based functional screening, antibody-antigen interaction analysis.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.

Additional Information
  • Requisition ID: 127621
  • Employment Status: Full-Time
  • Employee Status: Regular
  • FLSA: exempt and not eligible for overtime pay
  • Work Week: Day/Evening, Evenings, Rotating
  • Fund Type: Hard
  • Pivotal Position: Yes
  • Minimum Salary: US Dollar (USD) 48,000
  • Midpoint Salary: US Dollar (USD) 67,000
  • Maximum Salary : US Dollar (USD) 86,000
  • Science Jobs: Yes

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