Scientist - In Vitro Retinal Models
Deep Genomics is a Toronto-based startup company that is building an AI-powered discovery and development platform to significantly expand the universe of medicines available for genetically-defined diseases. Founded in 2015, Deep Genomics brings together a multidisciplinary team of world-leading experts in machine learning, genomics, chemistry, and biology. Together we are on a mission to rapidly discover and develop oligonucleotide drugs for the treatment of patients with severe disorders of the liver, central nervous system, and eye.
As Deep Genomics is expanding its portfolio of antisense oligonucleotide (ASO) therapeutics into IRDs (inherited retinal diseases), we are seeking a candidate with experience in advanced in vitro retinal models. This could include but is not limited to tissue engineering approaches such as organoids, bioprinting, microfluidics, or other combinations of stem cell derived systems.
Reporting to the Head of Preclinical Research, the candidate will be responsible for designing and monitoring stem cell derived in-vitro models, as well as using these models to determine ASO activity. While the initial priority will be to establish robust models using existing techniques, it is anticipated that the candidate will be motivated to innovate in this area. The candidate will work in close collaboration with other scientists in the experimental biology team and lead the assessment and implementation of new methods and models.
- PhD or equivalent with ≥ 3 years hands-on experience with advanced in vitro retina modeling from human pluripotent stem cells
- Deep knowledge of the developmental biology of the human retina and mechanisms involved in retinal degeneration
- An understanding of the generation and regeneration of the human photoreceptor, and of the photoreceptor light cycle and associated tissue dynamics
- Ideally, experience with the use of human stem cell derived in vitro retinal models to support therapeutic development
- Experience with the delivery of large molecules such as antibodies, proteins, or oligonucleotides to the human/animal retina or advanced in vitro retina systems.
- Experience with immunofluorescence, histology, electrophysiology, calcium signaling, mass spectrometry
- Familiarity with human genetics and inherited retinal diseases
- Superlative organizational, interpersonal, and communication skills
- A flexible attitude to job roles as well as a willingness to contribute wherever needed. The ideal candidate will take full ownership of their core responsibilities, and will be comfortable with those responsibilities evolving with the changing needs of the company.
- Comfortable working with limited supervision in a fast-paced and rapidly growing work environment. Previous experience working in a high-growth company is desirable.
What we Offer
- A highly competitive salary, health and dental benefits, and meaningful equity compensation.
- A collegial working environment with regular social events for team members and their families.
- You’ll also be joining a bright and highly-motivated team working at the intersection of the most exciting areas of science and technology.
Deep Genomics thanks all applicants, however only those selected for an interview will be contacted.
Deep Genomics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.