Post Doctoral Fellow

Employer
University of Utah School of Medicine
Location
Salt Lake City, Utah
Salary
Salary commensurate with experience and training.
Posted
July 11 2019
Discipline
Life Sciences, Virology
Position Type
Full Time
Organization Type
Academia

Postdoctoral Fellowship in Virology

POSTDOCTORAL FELLOWSHIP available in Virology at the University of Utah School of Medicine. NCI/NIH-funded projects focus on the host-pathogen relationship between oncogenic herpesviruses and the host cell.

Particular areas of interest are host restriction of virus reactivation and EBV and KSHV RNA-binding proteins involved in gene regulation. Targeting these proteins to discover novel antiviral compounds is an active area of research (See: Spironolactone blocks Epstein–Barr virus production by inhibiting EBV SM protein function, Verma D, Thompson D and Swaminathan S. PNAS March 29, 2016. 113 (13) 3609-3614). High throughput sequencing, recombinant molecular genetics and proteomics are being used to determine the role of virus proteins in modulating host cell gene expression and conversely, the role of cellular DNA binding proteins on virus reactivation.

Another area of interest is host epigenetic and immunologic methods of controlling EBV and KSHV replication.

(See: Li DJ, Verma D, Mosbruger T, Swaminathan S. CTCF and Rad21 Act as Host Cell Restriction Factors for Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Replication by Modulating Viral Gene Transcription. PLoS Pathog. 2014 Jan;10(1):e1003880. Epub 2014  and

Li D, Fu W, Swaminathan S. Continuous DNA replication is required for late gene transcription and maintenance of replication compartments in gammaherpesviruses. PLoS Pathog. 2018 May 29;14(5):e1007070. doi: 10.1371/journal.ppat.1007070. eCollection.)

Additional projects include investigating the mechanisms by which interferon-induced host proteins inhibit virus replication and oncogenic driver mutations/chromatin modifications in virus-associated lymphomas.

The successful applicant will be expected to contribute to planning experiments and writing manuscripts and grant applications in addition to carrying out bench research. A PhD or M.D. degree is required and experience in virology is highly desirable. An ability to work in a team environment is also important. If interested, please send CV and names of three references by e-mail to sankar.swaminathan@hsc.utah.edu.

Our laboratory is located in a newly renovated 4,000 square foot Infectious Diseases research facility in the Wintrobe Building at the University of Utah in Salt Lake City.  The University of Utah consistently ranks in the top 25 in the United States for federally funded research in public universities and awards over 2,000 graduate degrees annually.

The University of Utah is an Equal Opportunity/Affirmative Action employer and educator. Minorities, women, and persons with disabilities are strongly encouraged to apply. Reasonable accommodations provided. For additional information, see:

 http://www.regulations.utah.edu/humanResources/5-106.html

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