Postdoctoral position in biosensor design and applications at Institute for Protein Design at Univer

Employer
University of Washington
Location
Seattle, Washington State
Salary
NIH standard
Posted
July 08 2019
Ref
Biosensor design and applications
Position Type
Full Time
Organization Type
Academia
Job Type
Postdoc

Postdoctoral position in biosensor design and applications at Institute for Protein Design at Univer

The laboratory of Dr. Liangcai Gu in the Department of Biochemistry and the Institute for Protein Design (IPD) at the University of Washington School of Medicine invites applications for a postdoctoral position in designing metabolite biosensors and applying them to study metabolism and signaling in immune and nervous systems. The position is available immediately.

We use high-throughput screening and computation design approaches to create genetically encoded metabolite biosensors to dissect metabolic and signaling pathways with high spatiotemporal resolution. Particularly, we design chemically induced dimerization (CID) systems to create metabolite biosensors coupled with optical readouts (e.g., fluorescence and luminescence). We recently demonstrated an efficient, generalizable method (“COMBINES-CID”, https://pubs.acs.org/doi/10.1021/jacs.9b03522) for creating highly specific CID systems. Our method allows creating metabolite biosensors which have been difficult to obtain with other approaches.  Currently, we are developing fluorescent or luminescent biosensors for key metabolites as signaling molecules in gene regulation and signaling pathways.

Requirement:

Applicants should have a Ph.D. degree (or equivalent) in related fields including but not limited to biochemistry, cell biology, bioengineering, biophysics, immunology, and neuroscience. Highly desirable backgrounds/skills include i) mammalian cell culture, ii) phage or yeast display techniques for protein engineering; iii) quantitative fluorescence microscopy; iv) fluorescence activated cell sorting (FACS); v) molecular cloning and protein expression and purification.

Applicants should have a strong publication record, good spoken and written communication skills. Interested applicants should send i) a cover letter briefly describing your previous experience and your future research interests/plans, ii) a curriculum vitae, and iii) contact information of three references to Dr. Liangcai Gu (gulc@uw.edu).

Equal Employment Opportunity Statement

The University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.

Similar jobs

Similar jobs