Senior Research Specialist

A Senior Research Specialist position is available for someone with training (Ph.D. in pharmaceutical sciences, analytical chemistry, or equivalent) and specific expertise in analytical chemistry and pharmacology. Ongoing projects in our group are related to the identification of solute carriers for small molecule drugs (tyrosine kinase inhibitors, platinum chemotherapeutics, and nucleoside analogues) involved in drug uptake into hepatocytes, renal tubular cells, tumor cells, and normal cells affected by therapy such as epidermal keratinocytes and myeloid progenitors in bone marrow. The studies involve pharmacokinetic analyses and analytical measurements of drug and metabolic concentrations in biological matrices and cell culture using an array of techniques, including LC-MS/MS, F-AAS, and HPLC. The applicant will support and conduct experimental research within the Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, and will function as a technical expert on one or more phases of the projects. In particular, the applicant will be responsible for developing and validating quantitative bioanalytical methods; assist in the management of the research and development efforts; contribute to publications, progress reports and SOPs; prepare material for presentation at professional meetings; contribute to the writing of grant proposals; and work and train/educate other laboratory personnel.

Required Education: Doctorate (Academic) Required Education: A PhD in Pharmaceutical Sciences or equivalent is required.

Desired Education: A minimum of five (5) years of relevant and productive postdoctoral research experience in bioanalytical technology is desired.

Required Experience: Ability to conduct experiments with little to no supervision, and ability to direct and train other laboratory personnel. Basic core experience in the development and validation of bioanalytical methods as well as expertise in LC-MS/MS technology and data analysis is essential. In addition, the position requires extensive knowledge of and experience with the use of basic pharmacology techniques.

Desired Experience: Knowledge of the use and application of ADME-related techniques is considered desirable, including: drug formulation and stability, microsome-based assays, metabolism studies (cytochrome P450; glucuronidation), serum protein binding, blood cells partitioning, permeability studies (PAMPA, Caco-2, MDCK cells), determination of substrate transport (radiolabeled, fluorescent methods), evaluation of drug transport in cell lines and transporter vesicles, and protocol development bioanalytical analysis.

To apply for this position, please follow the direct link to The Ohio State University Careers website: https://www.jobsatosu.com/postings/75881 All applicants must apply through OSUJobs post. Contact Jay McKirnan (Jay.Mckirnan@osumc.edu) if you experience any issues with the application process.

The Ohio State University is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, or protected veteran status.

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