Manager, Analytical Operations

Employer
Moderna
Location
Cambridge, MA
Salary
Competitive
Posted
June 25 2019
Ref
R1702
Organization Type
Biotech
Manager, Analytical Operations

The Role:

The primary responsibilities of this role will be to support development and execution of high throughput analytical methods for messenger RNA therapeutic drug substance and drug products. The incumbent will work with analytical development, process development, and software engineers to increase TAT and capacity of current release methods for in-process testing. be expected to undertake laboratory work to support development, routine testing and data collation. Additional responsibilities include developing high throughput methods using liquid handling, novel technologies, and end-to-end sample tracking for drug substance/product components and impurities. This position will support cross-functional teams in Research and Development, Production and Quality. Additionally it is expected that the role will require the individual to generate technology transfer documents and enable the physical transfer of methods to receiving groups as part of a broader functional responsibility.

Here's What You'll Do:
  • Undertake analytical testing using established methods to generate high quality data to support process development.
  • Support development and transfer of novel techniques into routine testing environment.
  • Engage in automation and high throughput technologies to increase efficiency.
  • Perform verification and validation experiments.
  • Work with digital teams to enable end-to-end sample tracking from submission to final report of submissions.
  • Write analytical method SOP and train personnel on methods as needed.
  • Provide summary presentations and detailed reports to internal and external stake holders.
  • Maintain and troubleshoot equipment performance as needed.
  • Technology transfer of high throughput analytical methods to receiving partners, e.g. preclinical QC, non-GMP and GMP stability.
  • Provide subject matter expertise to support functions for methods that have been transferred.


Here's What You'll Bring to the Table:
  • PhD with 2-4 years, MS with 5-7 years, or BS with 7-10 years of relevant industry or undergraduate experience in analytical chemistry
  • PhD in Analytical Chemistry, Biochemistry, Chemical Engineering, or closely related field.
  • Knowledge of separation (e.g. HPLC, CE, cIEF), biophysical characterization (DLS, MALS), molecular biology (qPCR, ELISA), and spectrophotometric techniques (UV, fluorescence).
  • Knowledge of equipment platforms (e.g. Thermo, Waters, Agilent) and data processing software (e.g. Chromeleon, Chemstation, Empower).
  • Knowledge of nucleic acid chemistry and biology and standard methods of analysis of these molecules.
  • Hands on industry experience with analytical development for RNA and DNA therapeutics.
  • Demonstrable evidence of enabling high throughput analytical methods, including the use of liquid handlers/automation (e.g. with Hamilton or Tecan Robots)
  • Some experience of one or more of the following areas is a plus: Mass spectrometry, CD, CGE, IEF, GC.


Here's What We'll Bring to the Table:
  • Daily on-site catered lunches
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass
  • Free annual corporate membership to Bluebikes
  • Highly competitive healthcare coverage including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • 16 weeks of 100% paid parental leave for all new parents
  • 16 weeks 100% paid family caregiver leave
  • 20 weeks 100% paid medical leave
  • Adoption assistance and discounts to local childcare centers, as well as access to care.com
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays (includes 2 floating holidays)


Why join Moderna

At Moderna, we believe messenger RNA, or mRNA, is the "software of life." Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. Given its essential role, we believe mRNA could be used to create a new category of medicines with significant potential to improve the lives of patients.

Headquartered in Cambridge, Mass., Moderna currently has strategic alliances for development programs with AstraZeneca, Plc. and Merck, Inc., as well as the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense; and the Biomedical Advanced Research and Development Authority (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS). Moderna has been ranked in the top ten of Science's list of top biopharma industry employers for the past four years. To learn more, visit www.modernatx.com .

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

#LI-AG1

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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