Research Associate I - Systems Biology

Monrovia, California
June 25 2019
Position Type
Full Time
Organization Type
About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of

cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

We are seeking a talented and motivated Research Associate to work in the newly established laboratory of Dr. Srividya Swaminathan in the Department of

Systems Biology, City of Hope. We are focused on understanding the immune microenvironment surrounding B- and T- lymphoid malignancies. By comparing the global immune landscape during normal and malignant lymphopoiesis, we will identify immunotherapies that specifically target malignant lymphocytes. Our

research spans Hematology, Oncology, and Immuno-Oncology. We perform experiments with transgenic mouse models of lymphoid malignancies, primary human lymphoid cancer cells, humanized mice, transplantation models to study interactions between malignant lymphocytes and host immunity, gene editing, classical molecular and cell biology, and oncogenic signal transduction. Dr. Swaminathan's laboratory is funded by the Leukemia and Lymphoma Society (LLS), the American Society of Hematology (ASH), and City of Hope Start-Up.

Visit the Swaminathan Lab for details:

The RA will be responsible for assisting Dr. Swaminathan in laboratory setup,and helping postdoctoral fellows in techniques including but not limited to

flow cytometry, magnetic activated cell sorting, bioluminescence imaging, basic molecular biology and biochemistry techniques (RNA/DNA isolation,quantitative real time PCR, immunoblotting, immunofluorescence, Luminex, cloning, retro and lentiviral transductions), tissue culture, isolation and processing of immune cells, intra-peritoneal (IP), intravenous (IV), and intrafemoral injections in mice, and pre-clinical testing of immunotherapies in xenotransplantation models.

Key Responsibilities include:
  • Independently conduct experiments and maintain meticulous records of all experiments and their outcomes.
  • Assist the postdoctoral fellows in monitoring the general health of the mouse colonies.
  • Review literature on a regular basis to remain current with new procedures, and apply these to the ongoing research.
  • Contribute to publication of findings by conducting experiments and participating in writing protocols for the methods used.
  • Help with general lab maintenance as needed, maintain lab stock, manage reagent inventory and safety records, and provide general lab support as needed.
  • Assist in training of new lab personnel in procedures and techniques.
  • Other duties may be assigned as and when they arise.

Basic education, experience and skills required for consideration:
  • Bachelor's degree inImmunology, Cell, Molecular biology, or another field related to Life Sciences.
  • Working understanding of basic techniques and procedures related to the above fields, particularly Immunology.
  • Strong analytical skills, excellent judgment and strong work ethic.
  • Highly motivated, dedicated and independent.
  • Excellent oral and written communication skills.
  • Collaborative team player.
  • Excellent organizational skills and ability to work under deadlines as needed.
  • General computer skills (MS Word, Excel).
  • Strong desire to learn new techniques.
  • Strong understanding of basic scientific principles.
  • Excellent verbal and written communication skills. Excellent interpersonal skills.

Preferred education experience and skills:

  • Experience with flow cytometry (strongly desired).
  • Prior experience with handling mice and performing in vivo procedures is strongly desired because the individual will be working routinely with mice.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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