Sr Research Advisor-Translational Lead

Employer
Lilly
Location
Indianapolis, New York
Salary
Competitive
Posted
June 15 2019
Ref
50394BR
Discipline
Life Sciences
Position Type
Full Time
Organization Type
Pharma
Job Type
Other
The Oncology R&D organization is in the midst of a transformation agenda that will rely heavily on our competitiveness in Immuno-oncology. The IO Translational lead will lead translational efforts for the IO clinical development team, and will serve as a critical interface with the IO research and clinical teams as well as with our central diagnostics group . The ideal candidate will bring a strong sense of urgency around the unmet patient need, will push for speed and agility in all translational efforts, and will bring a collaborative spirit to enable disparate functions to drive a shared agenda. This role is a key member of the IO Lead Team, reporting to the VP Immuno-Oncology Medical Development and head of translational oncology research.

Key Deliverables
  • Provide management support and leadership for projects to evaluate biomarkers of immunomodulation in human specimens from internal clinical trials and external collaborations.
  • Lead a translational team comprising team members working in genomic evaluations, immunohistochemistry, FACs, and other immunoprofiling modalities to help guide research into resistance mechanisms and combination strategies for our IO franchise
  • Drive development of ex-vivo human model systems to evaluate novel IO targets and IO pipeline assets
  • Prioritize and manage multi-asset initiatives within Lilly for evaluation of potential biomarkers of response and/or resistance across IO programs and IO combination studies.
  • Accountable for working with research IT to guide development of centralized database of clinical outcomes data with relevant genomic, immunohistochemistry, cytokine, and other immune marker datasets from Lilly public private partnerships (ImmuCan) and Lilly IO trials that can be used to inform translational work for other IO programs.
  • Advise individual product teams develop priorities in specimen collection and evaluations from clinical trials required to inform the development of combination immunotherapy.
  • Lead development of pharmacodynamic assays to be used as part of clinical development
  • Responsible for leading collaboration efforts (industry and academic) around evaluation of assets in human specimens (short-term/long-term cultures and fixed specimens).
Work directly with the Diagnostics, Preclinical, and Clinical Immuno-Oncology teams to evaluate potential collaborations, analyses, and gaps specific to asset development in the immune-oncology space, particularly in settings that may not be as responsive to monotherapy with PD-1/PD-L1 inhibitors.

Company Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Basic Qualifications

  • An advanced scientific/medical graduate degree strongly preferred such as PharmD, PhD, or MD
  • Minimum 2 years oncology experience
  • Minimum 2 years of pharmaceutical experience


Additional Information

  • Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status


Additional Skills/Preferences

  • Experience in immune-oncology drug development; hematopathology; or immune biomarker development preferred.
  • MD PhD preferred
  • Industry experience preferred
  • Effective communication, collaboration and partnering skills

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