Postdoctoral Fellow in Protein Biophysics and Structural Biology

Cleveland, Ohio (US)
typically along NIH guidelines
June 10 2019
Position Type
Full Time
Organization Type
Job Type

Postdoctoral Fellow

in Protein Biophysics and Structural Biology

Postdoctoral Fellow in Protein Biophysics and Structural BiologyHow are signaling events transmitted? To answer this question we are looking to add a postdoctoral co-worker to our interdisciplinary team. Our interest is to understand protein-protein interactions, protein structure and dynamics in the context of cell signaling mechanisms. {e.g. see our recent papers Li, Z. & Buck, M, Structure 2017; Li, Z. et al., ACS Central Science 2018; Cao, S. et al., J.Biol.Chem. 2019, online 2/21; Li, Z.& Buck, M. bioRxiv online 2/24}. The systems include several small GTPases and their interacting partners, protein-membrane interactions, Eph receptors, plexins and coreceptors. The biological interest is in cell migration and positional maintenance with diseases ranging from vars. Cancers, Neuronal Degeneration in Alzheimers/Parkinson’s, Cardiovascular Disease and Age Related Macular Degeneration.

Research in protein biophysics/structural biology. We principally use solution NMR for protein structure determination, surface mapping and characterization of conformational change. The project may involve amide hydrogen exchange, NMR relaxation and molecular dynamics simulation as additional tools. NMR facilities at theNorthEast Ohio High Field NMR facility consist of a 600 MHz, 700 MHz, 800 MHz and a 900 MHz Bruker spectrometer. Apart from NMR, we employ other biophysical techniques and with the recent installation of a Titan Krios there is considerable interest to apply cryo-EM to our systems. Also the lab. has expertise in computational modeling and molecular dynamics simulations, which may be interesting for the candidate to learn.

We are looking for a talented and highly motivated coworker, who aims to become an independent researcher/project leader. Prior experience with protein NMR or crystallography is essential. The Buck laboratory provides a stimulating but friendly working environment. The Medical School of Case Western Reserve University is highly rated overall in the US (~ 16th. in terms of NIH funding) and Cleveland is a pleasant/culturally dense but affordable place to live with excellent educational, medical and arts institutions. Starting date, project details and salary are negotiable.Please send your resume, overview of your scientific interests and how working on projects in the Buck lab. would fit your career goals as well as contact details of three referees able to provide references by e-mail (address below)

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