Post Doc - Psychiatric Genetics and iPSC Research

NorthShore University HealthSystem
Evanston, Illinois
NIH Guidelines
June 07 2019
Position Type
Full Time
Organization Type
Job Type

Post Doc - Psychiatric Genetics and iPSC Research

NorthShore University HealthSystem (NorthShore) is a comprehensive, fully integrated, healthcare delivery system that serves the greater North Shore and Illinois communities. NorthShore is committed to earning the loyalty of those who come to us for care and those who play a role in providing that care.  Service Values which include:  Exceptional Customer Service, Supportive Workplace Interactions and Professional Work Ethic, define the behaviors that each employee demonstrates with co-workers, patients and families, physicians, and visitors.

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EOE: Race/Color/Sex/Sexual Orientation/ Gender Identity/Religion/National Origin/Disability/Vets, VEVRRA Federal Contractor. 

Looking for a self-motivated postdoctoral fellow to join the Unit of Functional Genomics in Psychiatry at the Center for Psychiatric Genetics of NUH. This position will be reporting to a PI/Supervisor who is an Associate Professor at the University of Chicago. The lab’s current research focus is on using patient-specific induced pluripotent stem cells (iPSC) and iPSC-derived neurons as a model to study molecular and neurobiological basis of schizophrenia and other brain disorders (Forrest MP, et a., Cell Stem Cell. 2017; Zhang S. et al. Stem Cell Res. 2018). The laboratory work will involve iPSC culture, neuron differentiation, open chromatin mapping, CRISPR/Cas9 genome editing, assaying functional effect of genetic perturbation on gene expression and cellular phenotypes in iPSC-derived neurons and brain organoids. In this role, you will have the opportunity to learn and take part in the computational analyses of large genomic datasets such as RNA-seq, ATAC-seq, etc. This position reports directly to the PI. This is a full-time position and is benefits eligible. 

In this role, you will:

  • Take a lead in work involved in multiple NIH funded projects
  • Work independently under supervision of the PI
  • Ability to prepare scientific manuscripts for publication
  • Ability to develop scientific proposals to apply for fellowships
  • Capable of identifying problems that may adversely affect experiment or reporting of results and of taking corrective action or notifying appropriate supervisory personnel
  • Comply with NorthShore University HealthSystem research guidelines
  • Follow Institutional Review Board (IRB) regulations and local, state, and federal research regulations
  • Ability to assist in submission of research applications, revisions, periodic progress reports

Our ideal candidates will have:

  • PhD required in a science field
  • Background in Molecular Biology, Neuroscience, Cellular Biology and/or Genomics preferred
  • Experience with stem cell culture and neuroscience research is preferred
  • Experience with computational analysis of genomic data is a plus
  • Strong comprehension of neuroscience, molecular biology/genetics or cellular biology
  • Excellent communication skills

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