POSTDOCTORAL RESEARCH FELLOW: DEVELOPMENT OF BEST-IN-CLASS CAR-T CONSTRUCTS EXPLORING SIGNALNG DOMAI

Employer
Johnson & Johnson
Location
Spring House, Pennsylvania
Salary
DOE
Posted
June 06 2019
Discipline
Other, Other
Position Type
Full Time
Organization Type
Pharma

POSTDOCTORAL RESEARCH FELLOW: DEVELOPMENT OF BEST-IN-CLASS CAR-T CONSTRUCTS EXPLORING SIGNALNG DOMAINS AND T CELL ACTIVATION(Job Number: 1930190104)

Description:

Caring for the world, one person at a time has inspired and united the people of Johnson & Johnson for over 130 years. We embrace research and science -- bringing innovative ideas, products and services to advance the health and well-being of people.

With $76.5 billion in 2017 sales, Johnson & Johnson is the world's most comprehensive and broadly-based manufacturer of health care products, as well as a provider of related services, for the consumer, pharmaceutical, and medical devices markets. There are more than 250 Johnson & Johnson operating companies employing over 125,000 people and with products touching the lives of over a billion people every day, throughout the world. If you have the talent and desire to touch the world, Johnson & Johnson has the career opportunities to help make it happen.

Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Janssen BioTherapeutics is searching for an energetic, highly-motivated Postdoctoral Fellow to drive the development of next-generation, solid tumor-based CAR-T therapies. Progress has been achieved targeting hematological malignancies with gene-edited T cells in the clinic; however, the efficacy of these targeted cell therapies in solid tumors remains marginal, leaving many unanswered questions. This postdoctoral fellow position will provide a rare opportunity to execute cutting-edge, bench-to-bedside research with the intent of delivering novel CAR-T therapeutics for solid tumor patients. The Research Fellow will partner throughout the Janssen R&D organization and participate in cross-functional team discussions, where the successful candidate will explore strategies to optimize the signaling domains of CAR constructs that lead to efficient signaling for T cell activation. Responsibilities will include determining the right signaling domains to incorporate in the CAR-T construct, exploring the interplay between endogenous TCRs and CAR constructs to improve the selective targeting of tumor tissue, and investigating the ability of bispecific CARs to deliver split-signals for T cell activation. Upon completion of the postdoctoral program, the Fellow will have acquired valuable career experience that enables entry into translational academic settings, biotech-related opportunities, and/or continued development in large pharma.

 

Qualifications:

Suitable candidates will have a recent PhD in immunology, immuno-oncology, or a related field. Research experience in one or more of the following areas is preferred :

  • Strong background in T cell signaling, TCR and CAR-T's mechanism of action
  • Hands on experience in tumor cell biology, T cell activation studies and basic T cell assay development
  • Research background in oncology and immunology
  • Must be able to work in US permanently


Candidates must display an ability to independently design and execute research. In addition to a broad knowledge of immunology and oncology, we are seeking an individual with deep intellectual curiosity, and excellent communication and interpersonal skills


Primary Location:
North America-United States-Pennsylvania-Spring House

Organization:
Janssen Research & Development, LLC. (6084)

Job Function:
Administration

Apply Here: http://www.Click2Apply.net/6qr6cp69ntxg6ng9

 

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