A postdoctoral fellow position is available in Dr. Morey’s lab at Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine. The Morey lab focuses on the epigenetic mechanisms that control cancer initiation and progression, and stem cell differentiation.
Previous work in our lab have shown that the architecture of Polycomb-group (PcG) complexes is instrumental in regulating stem cell fate decisions (Morey et al. Cell Stem Cell, 2012; Morey et al. Cell Reports, 2013; Morey et al. Cell Stem Cell, 2015). Recently, we have discovered that PcG complexes are recruited to active enhancers in multiple cancers, highlighting an under-explored function of PcG complexes in regulating oncogenic transcriptional programs in cancer (Chan et al. Nature Comm, 2018; Chan and Morey, Trends in Biochemical Sciences, 2019).
Our research program aims to characterize the PcG-mediated mechanisms in multiple cancer types, including breast cancer, and in human pluripotent stem cell differentiation. The projects will employ genetic, biochemical and genomic approaches including 3D chromatin architecture assays (HiC and HiChIP) and CRISPR/Cas9 screens, as well as standard genome-wide assays (ChIP- RNA- ATAC-seq). Experiments will be performed using both cell culture (cancer cells and human embryonic stem cells) and in vivo models (xenografts and PDX models).
Successful candidates will have earned a Ph.D. in genetics, molecular biology, cellular biology, or related fields and demonstrated the ability to complete research projects independently. Expertise in epigenetics in any model system will greatly strengthen the application. Experience with computational analysis of genomic data is a plus but is not required.
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Interested candidates are invited to contact Dr. Lluis Morey (email@example.com) with CV and names of two references.