Postdoctoral Fellow - Cancer Checkpoint Immunotherapy

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow in the Department of Molecular Medicine. The overarching goal of the research project is to investigate the mechanisms of specific small molecule CBP/catenin antagonists modulating the tumor immune response. The Wnt/ß-catenin signaling pathway is important in cancer therapy resistance, including immunotherapy. We have previously demonstrated that specific small molecule Wnt/CBP/catenin antagonists can safely overcome chemotherapy resistance (Zhao et al. 2016, Thomas and Kahn 2016, Kim Y.M. et al 2017).

Key Responsibilities include:

The current project will focus on the use of novel specific small molecule Wnt/CBP/catenin antagonists to augment immunotherapy in syngeneic mouse tumor models.

Basic education, experience and skills required for consideration:

• A Ph.D. degree in life or biomedical sciences, or a related discipline is required;
• Research experience in the fields of immunology and cancer biology;
• A publication record in peer-reviewed scientific journals;
• Experience with orthotopic and syngeneic mouse tumor models, FACS and immunohistochemistry is required;
• Ability to design and execute laboratory experiments, critically interpret experimental results, and present data in a clear and concise manner.

Additional Information:

• For more information about Dr. Kahn's research, please click here .

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.