Postdoctoral Associate - Human stem cell modeling of developmental disorders

Employer
Yale University
Location
New Haven, Connecticut
Salary
TBD
Posted
May 14 2019
Position Type
Full Time
Organization Type
Academia
Job Type
Postdoc

Postdoctoral Associate

Human stem cell modeling of developmental disorders

 

A Postdoctoral Associate position is available in the Vaccarino laboratory (http://medicine.yale.edu/lab/vaccarino/) at the Child Study Center, Yale University School of Medicine. The primary aim of the project is to use induced pluripotent stem cells (iPSC) to investigate the pathogenesis of autism spectrum disorders, Tourette syndrome and related conditions. The lab has generated large numbers of human iPSC lines from over 100 individuals from well-characterized cohorts of patients and their first- degree family members. The research focuses on generating and characterizing neuronal organoid derived from these iPSC lines, and performing multidisciplinary studies of phenotype, transcriptome, epigenome, and synaptic physiology, as well as integrative analyses. The applicant will be supported by the laboratory’s experience in organoid generation and bioinformatic analyses, and the laboratory’s library of viral vectors to perform cell type-specific tracing and analysis of synaptic connections. The candidate will have the opportunity to collaborate with bioinformaticians who are involved in the analysis of DNA structural and sequence variants. The applicant will also have the opportunity to probe the functional relevance of mutations in coding and noncoding regions by manipulating the genomes of induced pluripotent stem cells using CRISPR technologies to activate/repress enhancers and engineer mutations in iPSCs lines. Finally, the candidate will take advantage of the superb imaging core facilities at Yale University and will interact with experts in several other disciplines, including geneticists, physiologists, and system biologists.

The lab is in the Sterling Hall of Medicine, in the main Yale Medical School campus.  Qualified candidates should send a CV, a statement of research interests and the names of two references to monica.mleczek@yale.edu or flora.vaccarino@yale.edu.  The candidate must have a Ph.D. and/or M.D., should be an accomplished biomedical scientist with knowledge in molecular and cellular biology and preferably developmental neuroscience.  Excellent command of the English language is required.

Vaccarino lab:

http://medicine.yale.edu/lab/vaccarino/

Program in Neurodevelopment and Regeneration:

http://medicine.yale.edu/neurodevelopment/

 

Apply for Postdoctoral Associate - Human stem cell modeling of developmental disorders

Already uploaded your resume? Sign in to apply instantly

Apply

Upload from your computer

Or import from cloud storage

Your Resume must be a .doc, .pdf, .docx, .rtf, and no bigger than 1Mb


Upload from your computer

Or import from cloud storage

Your Supplementary Documents must be a .doc, .pdf, .docx, .txt, .rtf, and no bigger than 1Mb


4000 characters left

Marketing Communication

We'd love to send you information about Jobs and Services from Science Careers by email.

All emails will contain a link in the footer to enable you to unsubscribe at any time.


When you apply for a job we will send your application to the named recruiter, who may contact you. By applying for a job listed on Science Careers you agree to our terms and conditions and privacy policy. You should never be required to provide bank account details. If you are, please email us.

Similar jobs

Similar jobs