Post-Doctoral Research Fellow, Mechanisms of Prostate Cancer Resistance
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Program in Prostate Cancer Research and the Division of Human Biology seek a Postdoctoral Fellow to perform studies exploring the molecular mechanisms underlying cancer treatment resistance and the development of new therapeutics in Dr. Peter Nelson’s research group.
The particular areas of emphasis for this position center on studies of prostate cancer resistance to current therapeutics deployed to treat advanced prostate cancer including androgen receptor (AR) pathway antagonists, DNA damaging drugs, and immune-based agents. We are recruiting a post-doctoral fellow to engage in laboratory-based studies of these processes. This position will focus on delineating the molecular mechanisms driving treatment resistance that include cell intrinsic (e.g. mutation, cell plasticity, epigenetic) and microenvironment events, with opportunities for translational studies evaluating new clinical approaches that circumvent resistance mechanisms.
Ph.D. degree in biology; biochemistry; genetics; molecular biology; cell biology; immunology or related field is required. Additionally, experience in one of the following areas is required: genomics/genetics, analysis of inflammation/immune composition, biomarker characterization. Knowledge/exposure in biobanking, clinical trial design, and biostatistics is desired, as well as a demonstrated track record of high-quality publications. Expertise/skills in molecular biology techniques is required: RT-PCR, immunohistochemistry, ELISA, cell culture, drug toxicity assays. Candidates need to be highly-motivated, organized individuals who think independently but enjoy working as part of a dynamic, collaborative, and multidisciplinary team. Excellent verbal and written communication skills are essential.
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