Engineer III, Drug Product Process Development

Employer
Moderna
Location
Cambridge, MA
Salary
Competitive
Posted
June 29 2019
Ref
R1273
Discipline
Life Sciences, Biology
Organization Type
Biotech
Engineer III, Drug Product Process Development

The Role:

Moderna is seeking an Engineer III to join the Process Development group to develop, scale-up, and transfer new and improved production processes. The position will be based in Cambridge, MA and is expected to transition to the new Moderna Technology Center, currently under construction in Norwood, MA.

Moderna is developing first-in-class mRNA-based vaccines and therapeutics. The mRNA is packaged into lipid nanoparticles for storage and delivery. The Process Development group is focused on unit operations that are standard across the industry such as normal and tangential flow filtration and chromatographic purification. We are also designing scalable operations specifically invented to form our lipid nanoparticles, to encapsulate the mRNA, and to physically stabilize the particles.

Applicants should enjoy working in a fast-paced, dynamic, and innovative environment. The successful candidate will possess strong skills in designing and executing bioprocess experiments, and will collaborate through cross-functional matrix teams. The person in this role will have the opportunity to develop on-line analytics, process modelling, feedback control, and continuous processing. Results will be presented to broader groups allowing great exposure to CMC Strategy, Regulatory, MS&T, and Quality.

Here's What You'll Do:
  • Design, execute, and analyze experiments for existing and novel process modes
  • Define the process, the critical parameters, and the design space
  • Create high throughput and automated experimental setups
  • Own the development of scale-down models of manufacturing processes
  • Lead experiments to confirm robust process performance across the control space
  • Characterize nanoparticle properties through collaboration with the analytical team
  • Prepare process descriptions, technical reports, and communicate findings internally and externally as appropriate
  • Collect and share relevant academic literature, leverage external consultants/SMEs, and establish new collaborations with internal groups.


Here's What You'll Bring to the Table:
  • BS/MS degree in Bio/Chemical Engineering, Bio/Chemistry, Pharmaceutical Science, or related field
  • BS with 5-8 years, or MS with 2-5 years of relevant industry experience in bioprocess development
  • Hands on experience with chromatography, ultrafiltration, normal flow filtration, and development of innovative unit operations
  • Working knowledge of statistical design of experiments (DoE) and analysis of multivariate data
  • Experience with analytics and biophysical characterization of nanoparticles is a plus
  • Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and product commercialization
  • Knowledge of nucleic acid chemistry, lipid chemistry, and biology is a plus
  • Ability to thrive in a diverse and fast paced environment
  • Excellent written and verbal communication skills


Here's What We'll Bring to the Table:
  • Daily on-site catered lunches
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass
  • Free annual corporate membership to Bluebikes
  • Highly competitive healthcare coverage including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • 16 weeks of 100% paid parental leave for all new parents
  • 16 weeks 100% paid family caregiver leave
  • 20 weeks 100% paid medical leave
  • Adoption assistance and discounts to local childcare centers, as well as access to care.com
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays


Why join Moderna Therapeutics

At Moderna, we believe messenger RNA, or mRNA, is the "software of life." Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. Given its essential role, we believe mRNA could be used to create a new category of medicines with significant potential to improve the lives of patients.

Headquartered in Cambridge, Mass., Moderna currently has strategic alliances for development programs with AstraZeneca, Plc. and Merck, Inc., as well as the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense; and the Biomedical Advanced Research and Development Authority (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS). Moderna has been ranked in the top ten of Science's list of top biopharma industry employers for the past four years. To learn more, visit www.modernatx.com .

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

#LI-AG1

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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