I have an opening for postdoc to start immediately. My laboratory (https://kroncke-lab.github.io) aims to address the challenge of variants of uncertain significance (VUSs) in cardiac ion channels by blending experimental and computational strategies: 1) determine structure and flexibility-induced changes from selected ion channel variants using a combination of Rosetta modeling and molecular dynamics in AMBER. 2) generate experimental deep mutational scanning data sensitive to trafficking/functionally defective ion channel variants. 3) functionally characterize variants in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and 4) develop statistical predictive models of arrhythmia phenotypes. These technologies enable us to construct predictive models of ion channel phenotypes (functional and clinical) and validate resulting predictions.