Postdoc

Location
Nashville Tennessee (US)
Salary
Salary will be set commensurate with experience and accomplishments as well as NIH guidelines
Posted
May 02 2019
Ref
Postdoc in Heart Arrhythmias Genetics!
Position Type
Full Time
Organization Type
Academia

I have an opening for postdoc to start immediately. My laboratory (https://kroncke-lab.github.io) aims to address the challenge of variants of uncertain significance (VUSs) in cardiac ion channels by blending experimental and computational strategies: 1) determine structure and flexibility-induced changes from selected ion channel variants using a combination of Rosetta modeling and molecular dynamics in AMBER. 2) generate experimental deep mutational scanning data sensitive to trafficking/functionally defective ion channel variants. 3) functionally characterize variants in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and 4) develop statistical predictive models of arrhythmia phenotypes. These technologies enable us to construct predictive models of ion channel phenotypes (functional and clinical) and validate resulting predictions.

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