Sr. Research Associate, DNA Process Development

Employer
Moderna
Location
Cambridge, MA
Salary
Competitive
Posted
June 26 2019
Ref
R1397
Organization Type
Biotech
Sr. Research Associate, DNA Process Development

The Role:

Moderna is working to develop first-in-class messenger RNA (mRNA) based medicines. DNA and Enzymes Process Development, a process development team residing in Moderna's Technical Development organization, has been tasked with development and implementation of processes to produce DNA and Enzymes utilized in the production of RNA. The role will initially start in Cambridge and will eventually transition to Moderna Technology Center in Norwood.

Our efforts in this area are growing, and Moderna is seeking a new team member to join the DNA and Enzymes Process Development Unit . In this role, you will have the opportunity to develop commercialize processes to facilitate mRNA production processes, as well as DNA purification. The incumbent will collaborate closely with Moderna's core platform process development, analytical development and process automation teams to adapt existing technologies or develop new technologies for application in personalized medicine manufacturing. Our goal is to enable clinical studies and one-day commercial manufacturing, so you will work closely with multiple functions spanning development, technical operations and manufacturing.

The successful candidate must be able to work in a fast paced and highly dynamic environment, will have relevant academic and or industrial experience in large molecule bioprocessing, and will be able to contribute to both process development and commercialization related activities.

Here's What You'll Do:
  • Design and execute studies to identify novel methods to purify biomolecules
  • Optimize current processes to ease of manufacturing, cost, and to facilitate improved characteristics to aid in the production of mRNA therapeutics.
  • Collaborate with analytics, development, technical operations and manufacturing on process design
  • Perform routine analytical characterization of process intermediates using HPLC/UPLC, SDS-PAGE and agarose gels, UV-Vis spectroscopy
  • Develop new innovative processes to fit manufacturing needs.
  • Facilitate technology transfer to Pilot and GMP manufacturing teams
  • Maintain thorough electronic lab notebooks and documentation records
  • Present results in cross-functional meetings


Here's What You'll Bring to the Table:
  • BS in Chemical Engineering, Chemistry, Biochemical Engineering, Biochemistry or closely related field, and 0-3 years relevant industry experience.
  • Working knowledge of bioprocess engineering principles, process modeling, and Design of Experiment (DoE) statistical tools.
  • Familiarity with nucleic acid and protein chemistry, enzyme kinetics, and analytical characterization of biomolecules
  • Ability to plan and execute experiments independently
  • Creative/innovative/problem solver
  • Excellent communication, presentation, and writing skills


Here's What We'll Bring to the Table:
  • Daily on-site catered lunches
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass
  • Free annual corporate membership to Bluebikes
  • Highly competitive healthcare coverage including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • 16 weeks of 100% paid parental leave for all new parents
  • 16 weeks 100% paid family caregiver leave
  • 20 weeks 100% paid medical leave
  • Adoption assistance and discounts to local childcare centers, as well as access to care.com
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays


Why join Moderna Therapeutics

At Moderna, we believe messenger RNA, or mRNA, is the "software of life." Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. Given its essential role, we believe mRNA could be used to create a new category of medicines with significant potential to improve the lives of patients.

Headquartered in Cambridge, Mass., Moderna currently has strategic alliances for development programs with AstraZeneca, Plc. and Merck, Inc., as well as the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense; and the Biomedical Advanced Research and Development Authority (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS). Moderna has been ranked in the top ten of Science's list of top biopharma industry employers for the past four years. To learn more, visit www.modernatx.com .

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

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Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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