Director, DMPK

Employer
Moderna
Location
Cambridge, MA
Salary
Competitive
Posted
May 01 2019
Ref
R1611
Discipline
Life Sciences, Biology
Organization Type
Biotech
Director, DMPK

The Role:

The Director of DMPK is responsible for leading the DMPK function for discovery projects from early target validation stages to the nomination of the development candidate. The Director will be responsible for establishing the DMPK strategy and working with various CROs on the in vitro and in vivo ADME, PK, PK/PD, and TK studies and ensure timely data-driven decision making. The candidate should have strong understanding of DMPK and PK/PD areas applicable to animal models and translation into humans. The Director will be responsible for analyzing and interpreting DMPK and PK/PD data and disseminating results in a multidisciplinary team environment.

Here's What You'll Do:

The candidate will be responsible for:
  • Designing and executing preclinical studies to understand the ADME and PK characteristics of development candidates
  • Representing DMPK as the subject matter expert on multidisciplinary project teams
  • The analysis and interpretation of preclinical DMPK data
  • Managing external vendors in the conduct of in vitro/in vivo ADME studies.
  • Establishing ADME strategies that meet regulatory requirements and program goals
  • Leading the growth of Moderna's DMPK capabilities and developing industry leading technologies to support the development of Moderna's drug products
  • Coaching, mentoring and career development of staff
  • Presenting data, collaborative findings, and plans to Moderna management, partners and collaborators, conferences and regulatory meetings as appropriate


Here's What You'll Bring to the Table:
  • PhD or PharmD with a focus in pharmacokinetics, pharmacology, pharmaceutics or other related
  • PhD with at least 10 years of relevant experience including 3+ years of management experience
  • Demonstrated knowledge of ADME principles, PK/PD and bioanalytical concepts
  • Strong publication record in the area of DMPK
  • Experience in contributing DMPK components for submission to regulatory authorities
  • Ability to develop and deliver clear and concise presentations for both internal and external meetings
  • Candidate will be curious in exploring new path for drug discovery, bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes
  • Outstanding written and verbal communication skills


Here's What We'll Bring to the Table:
  • Daily on-site catered lunches
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass
  • Highly competitive healthcare coverage including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • 16 weeks of 100% paid parental leave for all new parents
  • 16 weeks 100% paid family caregiver leave
  • 20 weeks 100% paid medical leave
  • Adoption assistance and discounts to local childcare centers, as well as access to care.com
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays (includes 2 floating holidays)


Why join Moderna

At Moderna, we believe messenger RNA, or mRNA, is the "software of life." Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. Given its essential role, we believe mRNA could be used to create a new category of medicines with significant potential to improve the lives of patients.

Headquartered in Cambridge, Mass., Moderna currently has strategic alliances for development programs with AstraZeneca, Plc. and Merck, Inc., as well as the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense; and the Biomedical Advanced Research and Development Authority (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS). Moderna has been ranked in the top ten of Science's list of top biopharma industry employers for the past four years. To learn more, visit www.modernatx.com .

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

#LI-BG1

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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