The Yeaman laboratory in the Department of Anatomy and Cell Biology at the University of Iowa is seeking a motivated, focused and skilled Postdoctoral Fellow. Our group is interested in identifying molecular mechanisms responsible for biogenesis of epithelial cell polarity (publications in Cell, Molecular Cell, Nature Cell Biology, J. Cell Biol., etc). We study details of fundamental cellular processes, such as intercellular adhesion, cytoskeletal remodeling and membrane trafficking, that are at the foundation of tissue development and organogenesis. Our focus is on the Exocyst, a multi-functional, allosterically regulated scaffold, and Ral GTPases, which regulate Exocyst functions by facilitating association or disassociation with additional proteins. We utilize CRISPR/Cas9 gene editing, along with mouse models, 2D and 3D cell culture models, cutting edge cell imaging technologies and biochemical assays to understand how Exocyst protein assemblies function during cell growth and differentiation, motility and cell division. We are performing focused structure-function studies in efforts to understand how specific mutations in genes encoding Exocyst and Ral proteins contribute to human diseases including cancers, diabetes and ciliopathies. The University of Iowa Carver College of Medicine is a highly ranked biomedical research institute. The Yeaman laboratory is located in a state-of-the-art facility that features a collaborative atmosphere to foster innovation.
Qualifications: Interested candidates should have obtained a Ph.D. or M.D. degree with a strong background in molecular biology, cell biology and biochemistry. The ideal candidate will have proven talent to work independently with excellent interpersonal and communication skills.
- Solid knowledge in Cell and Molecular biology and Biochemistry;
- Extensive experience working with mammalian cell lines and primary cells (ideally polarized epithelial cultures grown on Transwells or in Matrigel);
- Extensive experience with PCR, RT-PCR, molecular cloning, CRISPR/Cas9;
- Experience with TIRF, super-resolution microscopy, confocal microscopy and electron microscopy;
- Experience in mouse handling, genotyping, mouse surgeries, tissue dissection.
To apply for this position visit our website at http://jobs.uiowa.edu; requisition # 2971.
The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran. Applicants’ credentials are subject to verification.