Sr./Research Associate, DNA Development

Employer
Moderna
Location
Norwood, MA
Salary
Competitive
Posted
March 31 2019
Ref
R1555
Organization Type
Biotech
Sr./Research Associate, DNA Development

The Role:

Moderna is seeking a new team member to join the DNA and Enzymes Process Development Unit for a position based at the Norwood, MA site. Reporting to the Principal Engineer, the Sr./Research Associate will have the opportunity to develop and commercialize production strains, vectors, and processes to facilitate Moderna's mRNA production processes; with a focus on applying state of the art molecular biology tools to develop rapid and low-cost methods for producing clinical grade DNA for Moderna's clinical pipeline. The incumbent will collaborate closely with Moderna's core platform research, process development, analytical development, and process automation teams to adapt/develop new technologies for application in plasmid and enzyme manufacturing. Our goal is to enable clinical studies and one-day commercial manufacturing, so you will work closely with multiple functions spanning development, technical operations and manufacturing.

The successful candidate must be able to work in a fast paced and highly dynamic environment, will have relevant academic and or industrial experience in molecular biology, metabolic engineering, or microbial strain development, and will be able to contribute to both process development and commercialization related activities.

Here's What You'll Do:
  • Design and execute studies to identify potential strain and process improvements
  • Help develop new technologies for strain development, DNA synthesis and enzyme manufacturing
  • Perform routine analytical characterization of process intermediates using HPLC/UPLC, SDS-PAGE and agarose gels, UV-Vis spectroscopy
  • Collaborate with analytics, development, technical operations and manufacturing
  • Maintain thorough electronic lab notebooks and documentation records
  • Present results in cross-functional meetings


Here's What You'll Bring to the Table:
  • BS in Chemical or Biochemical Engineering, Molecular Biology, Biochemistry, or closely related field with 2-5 years relevant industry experience; OR MS with 1-2 years relevant industry experience
  • Significant experience with molecular biology techniques related to strain development and synthetic biology (PCR, gene cloning, primer design, bacterial transformation and cell culture)
  • Knowledge of fermentation, metabolic engineering techniques and/or microbial metabolic pathways a plus
  • Outstanding communication skills (verbal and written).
  • Ability to manage multiple projects in a fast-paced environment.
  • Ability to effectively collaborate effectively in a dynamic, cross-functional matrix environment.


Here's What We'll Bring to the Table:
  • On-site subsidized cafeteria
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass
  • Highly competitive healthcare coverage including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • 16 weeks of 100% paid parental leave for all new parents
  • 16 weeks 100% paid family caregiver leave
  • 20 weeks 100% paid medical leave
  • Adoption assistance and discounts to local childcare centers, as well as access to care.com
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays


Why join Moderna Therapeutics

Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. mRNA medicines are designed to direct the body's cells to produce intracellular, membrane or secreted proteins that can have a therapeutic or preventive benefit and have the potential to address a broad spectrum of diseases. Moderna's platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, providing Moderna the capability to pursue in parallel a robust pipeline of new development candidates. Moderna is developing therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases and cardiovascular diseases, independently and with strategic collaborators.

Headquartered in Cambridge, Mass., Moderna currently has strategic alliances for development programs with AstraZeneca, Plc. and Merck, Inc., as well as the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense; and the Biomedical Advanced Research and Development Authority (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS). Moderna has been ranked in the top ten of Science's list of top biopharma industry employers for the past four years. To learn more, visit www.modernatx.com .

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

#LI-AG1

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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