Sr./Research Associate, Analytical Development

Employer
Moderna
Location
Norwood, MA
Salary
Competitive
Posted
March 29 2019
Ref
R1549
Organization Type
Biotech
Sr./Research Associate, Analytical Development

The Role:

The primary responsibilities of this role will be to support the testing of in-process controls (IPC) using established analytical methods including both chemical separation and biophysical techniques to support large scale manufacturing process of messenger RNA therapeutic drug substances and drug products. The incumbent will be expected to undertake laboratory work to support the IPC testing during the manufacture of critical non-GMP and GMP large scale batches including IND-enabling and toxicology drug substance and drug product batches.

Additional responsibilities include troubleshooting analytical methods when required, trending analytical method performance, serving as a SME to support cross-functional groups including GMP quality control and preclinical production/QC groups, and supporting drug substance and drug product non-GMP/GMP investigations.

This role will be located in Norwood, MA. The individual will be a key contributor to large scale non-GMP drug substance and drug product manufacture at Moderna's new manufacturing facility in Norwood, MA.

Here's What You'll Do:
  • Undertake analytical testing using established methods to generate high quality data to support development and toxicology batch manufacturing process.
  • Troubleshoot analytical instrumentation and methods as required, and trending analytical method performance.
  • Provide data summary presentations and detailed tech reports to internal and external stake holders.
  • Maintain good GLP lab and documentation practices.
  • Support implementation of new assays from analytical development, test method generation, and SME responsibilities supporting method transfers to QC.


Here's What You'll Bring to the Table:
  • BS with 3-5 years of relevant industry experience or relevant undergraduate experience in analytical chemistry.
  • BS/MS in Analytical Chemistry, Biochemistry, Chemical Engineering, or closely related field.
  • Knowledge and extensive hands-on experience of HPLC, modes of separation (e.g. ion exchange, reverse phase ion pairing, size exclusion) and DLS. Knowledge of biophysical techniques, GC/MS and LC/MS is a plus.
  • Knowledge and extensive hands-on experience of equipment platforms (e.g. Thermo, Waters, Agilent) and data processing software (e.g. Chromeleon, Empower and Openlab).
  • Familiarity with electronic notebooks, LES and LIMS
  • Knowledge of nucleic acid chemistry and biology and standard methods of analysis of these molecules


Here's What We'll Bring to the Table:
  • On-site subsidized cafeteria
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass
  • Highly competitive healthcare coverage including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • 16 weeks of 100% paid parental leave for all new parents
  • 16 weeks 100% paid family caregiver leave
  • 20 weeks 100% paid medical leave
  • Adoption assistance and discounts to local childcare centers, as well as access to care.com
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays


Why join Moderna Therapeutics

At Moderna, we believe messenger RNA, or mRNA, is the "software of life." Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. Given its essential role, we believe mRNA could be used to create a new category of medicines with significant potential to improve the lives of patients.

Headquartered in Cambridge, Mass., Moderna currently has strategic alliances for development programs with AstraZeneca, Plc. and Merck, Inc., as well as the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense; and the Biomedical Advanced Research and Development Authority (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS). Moderna has been ranked in the top ten of Science's list of top biopharma industry employers for the past four years. To learn more, visit www.modernatx.com .

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

#LI-KD1

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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