Senior/Principal Scientist, DMPK

Cambridge, MA
March 14 2019
Life Sciences, Biology
Organization Type
Senior/Principal Scientist, DMPK

The Role:

The Senior/ Principal Scientist of DMPK will be responsible for establishing the DMPK strategy to support advancement of Moderna's mRNA technology platform and pipeline . The role will lead the in vitro and in vivo ADME, PK, PK/PD, and TK efforts, design and execute experiments, and manage collaborations with CROs to ensure timely data based decision making. The candidate should have strong understanding of DMPK and PK/PD areas applicable to animal models and translation into humans. Will be responsible for analyzing and interpreting DMPK and PK/PD data and disseminating results in a multidisciplinary team environment.

Here's What You'll Do:
  • Designing and executing preclinical studies to understand the ADME and PK characteristics of development candidates
  • Representing DMPK as the subject matter expert on multidisciplinary project teams
  • The analysis and interpretation of preclinical DMPK data
  • Managing external vendors in the conduct of in vitro/in vivo ADME studies.
  • Establishing ADME strategies that meet regulatory requirements and program goals
  • Participating in the preparation of abstracts and manuscripts for publication

Here's What You'll Bring to the Table:
  • PhD with a focus in pharmacokinetics, pharmacology, pharmaceutics or other related field and at least 2-5 years drug development experience, or an MSc with at least 10 years drug development experience
  • Demonstrated knowledge of ADME principles, PK/PD and bioanalytical concepts
  • Strong publication record in the area of DMPK
  • Experience in contributing DMPK components for submission to regulatory authorities
  • Ability to develop and deliver clear and concise presentations for both internal and external meetings
  • Candidate will be curious in exploring new path for drug discovery, bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes
  • Outstanding written and verbal communication skills

Here's What We'll Bring to the Table:
  • Daily on-site catered lunches
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass
  • Highly competitive healthcare coverage including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • 16 weeks of 100% paid parental leave for all new parents
  • 16 weeks 100% paid family caregiver leave
  • 20 weeks 100% paid medical leave
  • Adoption assistance and discounts to local childcare centers, as well as access to
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays

Why join Moderna Therapeutics

At Moderna, we believe messenger RNA, or mRNA, is the "software of life." Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease. Given its essential role, we believe mRNA could be used to create a new category of medicines with significant potential to improve the lives of patients.

Headquartered in Cambridge, Mass., Moderna currently has strategic alliances for development programs with AstraZeneca, Plc. and Merck, Inc., as well as the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense; and the Biomedical Advanced Research and Development Authority (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS). Moderna has been ranked in the top ten of Science's list of top biopharma industry employers for the past four years. To learn more, visit .

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.


Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Similar jobs

Similar jobs