Postdoctoral position is available now at the UCSF Helen Diller Family Comprehensive Cancer Center at the mission bay campus for an outstanding candidate interested in cancer biology or translational cancer research. Our laboratory is interested in tyrosine kinase oncogenes in epithelial cancers, with a focus on the HER and Src family of oncogenes. We are interested in understanding how the functions of HER2 and HER3 are engaged in constitutive signaling seen in the tumorigenic state of overexpression, how the downstream circuitry is altered because of it, and how and why tumors develop an irreversible addiction to this oncogenic signal. This work builds on a substantial body of data and model systems already established in our lab. We are also interested in resolving the paradox regarding Src kinases. Despite an abundance of evidence regarding the transforming potential of Src kinases, their role in human cancers remains unproven and response to Src inhibitors unimpressive. But new evidence, developed in our lab, has shed new light on how their function may be engaged in human cancers.
Our work encompasses a wide range of in vitro and in vivo experimental techniques including protein biochemistry and signaling, gene expression, gene knockdown and knockout models, mouse xenograft and genetic models, and interrogation of clinical samples. We are also involved in several drug discovery efforts to test novel interventional strategies. UCSF is a highly collaborative environment and our laboratory is involved in collaborations with multiple other research programs within the scientific community including programs in systems biology, small molecule discovery, chemistry and chemical biology, and structural biology. We are also actively engaged in translating our laboratory-derived findings into clinical trials conducted at the cancer center. More information available at www.lab.moasser.com. Highly motivated candidates with an MD or PhD and a strong background in molecular and cellular biology please send CV to Mark M. Moasser, MD at email@example.com