Postdoctoral Fellow Position
Harvard Medical School
We are seeking highly motivated postdoctoral fellows to study pathogenic mechanisms of Alzheimer's and Parkinson’s disease and to develop novel therapies in the laboratory of Prof. Jie Shen at Harvard Medical School and Brigham and Women’s Hospital (www.shenlab.net). We employ mouse and Drosophila genetic approaches to elucidate functions of gene products involved in Alzheimer’s and Parkinson’s disease in relevant neural circuits and identify molecular pathways regulated by the disease genes. We also use cell culture, biochemical, imaging and viral approaches to investigate molecular and cellular mechanisms. Our work is funded by five NIH grant awards including a center grant. Areas of research include:
Alzheimer’s disease: We apply state of the art genetic approaches to dissect the physiological roles of Presenilins and the amyloid precursor protein (APP), two major gene families linked to familial Alzheimer’s disease, in the developing and adult brain. We also investigate the cellular and molecular mechanisms by which mutations in Presenilins and APP cause dementia and neurodegeneration. Some of our publications include Nature 460:632-6, J Biol Chem 285:22350-9, J Neurosci 32:5085-5096, PNAS 110:15091-6, PNAS 111:8973-8, Neuron 85: 967-81, J Neurosci 34: 15912-22, Neuron 90: 417-422, Genetics 206: 1479-93.
Parkinson’s disease: We are part of the BWH Udall Center of Excellence for Parkinson’s disease (udallcenter.bwh.harvard.edu), one of the 9 NIH funded Udall Centers across the country. Our center focuses on the interplay between LRRK2 and alpha-synuclein, and includes the Südhof lab at Stanford and the Yue Lab at Mt. Sinai School of Medicine. Relevant publications include PNAS 106:14622-7, PNAS 107:9879-84, Mol Neurodegen 7:2, and Neuron 96:796-807.
Recent PhDs with strong expertise in the following areas 1) molecular biology and mouse genetics; 2) fly genetics; 3) stereotaxic injection; or 4) slice electrophysiology are encouraged to send CV to Dr. Jie Shen at email@example.com. Successful candidates should be dedicated scientists who enjoy working independently and collaboratively, and are motivated by their desire to better understand disease mechanisms and bring effective therapies to patients.