The Pantophlet Lab is eager to recruit a junior postdoctoral researcher for studies focused on influenza vaccine design and development. A 4-year CIHR-funded project is available aimed at determining the immunogen requirements for priming and promoting the development of hetero-subtypic neutralizing antibodies to the stem region of flu HA. This requirement will be probed in vitro and in vivo; the latter will be assessed with animals transgenic for human antibody genes, thus serving as a surrogate system for human antibody responses. The objective is to fill gaps in our understanding of how best to stimulate the development of broadly reactive antibodies, from germline precursor to mature counterpart.
Required scientific background and expertise:
1) A PhD or MD/PhD degree in immunobiology, viral immunology, microbial pathogenesis, vaccinology or other closely-related discipline within the last 9 months with publications in mid- to top-tier journals
2) High proficiency with the following techniques :
o Mammalian cell culture;
o Molecular biology;
o Affinity chromatography (for protein purification)
o Multi-color flow cytometry;
o Surface Plasmon Resonance or Bio-layer interferometry
Preference will be given to applicants experienced in B cell immunology or B cell repertoire analyses. Knowledge of anti-viral immune responses will be considered assets. Applicants must also have demonstrable experience in designing experiments independently, excellent verbal and written English communication and organizational skills and demonstrable ability to draft manuscripts for publication.
Opportunity will be available for professional development via the Office for Graduate and Postdoctoral Studies. Salary will be commensurate with stipend levels of a CIHR postdoctoral fellowship, albeit that successful applicants are expected to be sufficiently competitive to apply for external postdoctoral funding (e.g. from CIHR) within the first 12 months. The post is full-time and for 2 years initially, with possibility for extension based on performance and funding.
How to apply
To be considered, applicants should send an email to Dr. Ralph Pantophlet (rpantophlet[at]sfu.ca) that must include:
1) A clear and specific description of short- and long-term career goals and how joining the Pantophlet Lab fits within these goals;
2) A detailed academic CV; and
3) The names of three academic references.
All applicants meeting the criteria above are encouraged to apply, albeit that preference will be given to Canadian citizens and those with Canadian permanent residency. The position is available starting April 1, 2019. Applications will be continually reviewed until a suitable candidate is identified.