Merck Sharp & Dohme Corp
South San Francisco, California
Commensurate with experience
February 07 2019
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.


South San Francisco, CA
Job # RES002238

Merck is currently seeking a qualified synthetic organic chemist to join the Discovery Process Chemistry (DPC) group at our San Francisco, CA site.

The core responsibility of the successful candidate will be to lead a team of scientists in the development of innovative solutions to complex chemistry problems across a diverse portfolio of projects in the discovery phase, from lead identification through candidate selection, with the goal to apply these solutions to facilitate medicinal chemistry research by overcoming synthetic bottlenecks, streamlining SAR analogue synthesis, and providing access to novel chemical space. The position is also responsible for defining scalable synthetic routes and successfully transitioning candidate compounds from discovery into early development, as well as managing supply of Active Pharmaceutical Ingredients (APIs) at varying scales during this period. Close collaboration with chemistry colleagues in Medicinal Chemistry and Process Chemistry, as well as a broad array of other discovery and preclinical research groups, will be expected. As such, subject matter expertise in Process or Medicinal Chemistry is critical.

The candidate must be highly self-motivated, demonstrate exceptional leadership and mentorship skills, possess strong experimental skills, have excellent written and oral communication abilities, collaborate effectively on multidisciplinary teams, and be able to demonstrate flexibility in adapting to change in a fast-paced, dynamic research environment. In addition to supervising direct scientific reports, the candidate is also expected to provide broader mentorship and expertise across the DPC group. The candidate will be expected to remain current with the latest synthetic methodologies, drive innovation, actively apply new concepts to continuously improve PR&D capabilities and expertise, and be active in the external scientific community via publications and external presentations.


Education Minimum Requirement:

- PhD in Organic Chemistry or related field.

Required Experience and Skills:

- A minimum of 5 years experience with a proven track record of scientific excellence and successful research in process and/or medicinal chemistry
- Established scientific reputation supported by peer-reviewed publications and external presentations
- Expertise in organic synthesis
- Demonstrated creativity and innovation in problem solving
- Productivity and efficiency working in the lab
- Strong written and oral communication skills
- Excellent collaboration skills
- Ability to contribute to and lead cross-functional teams and influence team strategy and decision-making
- Demonstrated ability to develop talent through good mentoring skills

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at

To be considered for this position, please visit our career site at, search jobs, create a profile and submit your resume for requisition #RES002238 to:

Merck is an equal opportunity employer, Minority/Female/Disability/Veteran - proudly embracing diversity in all of its manifestations.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster
EEOC GINA Supplement
OFCCP EEO Supplement