Atlanta, Georgia
Competitive salaries and may include equity
January 26 2019
Position Type
Full Time
Organization Type

Chemists needed for RNA therapeutics / gene editing startup

Guide Therapeutics is a startup company that has developed a proprietary and patented ‘DNA barcoding’ approach to analyze how up to 500 different nanoparticles deliver DNA / RNA drugs in a single animal. By generating 75,000 to 100,000 in vivo drug delivery datapoints per experiment, and analyzing these data using a proprietary nanoparticle bioinformatics pipeline, Guide can rapidly discover nanoparticles that deliver therapeutic DNA / RNA to new tissues and cells.

Guide values its team and believes in creating a dynamic environment that allows employees to (i) think creatively and (ii) rapidly pursue cutting-edge scientific ideas. Guide Therapeutics is hiring chemists interested in developing novel drug delivery vehicles for siRNA, mRNA, or gene editing therapeutics. The chemists will synthesize novel structures; the structures will be rapidly tested in vivo, to evaluate whether they can be used as a clinically relevant delivery vehicle for DNA or RNA drugs. We are specifically interested in chemists with a Ph.D. in organic, synthetic, or medicinal chemistry. Industry experience is a plus, but is not a requirement. 

This is a unique opportunity for several reasons. First, you will be a member of a fun, passionate, and interdisciplinary group of scientists. Second, you will learn about ‘nanoparticle DNA barcoding’, a new approach that combines high throughput chemistry, in vivo drug delivery, genomics, and bioinformatics. Third, you will interact with leaders in gene therapy; we have direct connections to leaders in academia and established companies. Finally, you will be able to live in Atlanta, a thriving, welcoming city. Atlanta is known for its young professional culture, as well as its access to great food, music, hiking, breweries, and museums. Salaries go much farther in Atlanta than in Boston or San Francisco; in addition to salary, this offer may include equity in Guide.

Since Guide does not support H1B visas, U.S. Citizens or scientists with a green card should apply. Guide is an equal opportunity employer; we are a team that fully supports our scientists, independent of their personal beliefs or experiences. For additional information, visit To learn about nanoparticle DNA barcoding, visit or If interested in applying, please send a CV to Tom Saylor (CEO,, Cory Sago (founding scientist,, or Georgia Tech professor James Dahlman (co-founder,