Postdoctoral Fellow - Cell Signaling of Pancreatic Beta-Cell Development and Maturation

Duarte, California
January 13 2019
Position Type
Full Time
Organization Type
About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow. The position is available in the laboratory of Dr. Shih, at the Diabetes and Metabolism Research Institute. The group is looking for a highly motivated postdoctoral fellow interested in studying the cell signaling regulation of pancreatic development and beta-cell maturation in animal models, as well as stem-cell based systems. In addition, the lab is interested in studying the cell-environment and cell-cell interaction in fetal and neonatal pancreas development. The lab utilizes genetic mouse models, stem cell biology and imaging techniques to study the cellular identity, function, remodeling, and maturation of beta-cells during development and adult maintenance.

The ideal candidate will have extensive experience in molecular biology and cell or developmental biology. Experience with histology/imaging techniques and rodent models preferred. The candidate should be self-motivated, with a proven track record of productivity.

Key Responsibilities include:

The specific research projects currently available in the lab are directed at determining: the role of environmental cues in controlling pancreas development. The functional requirement cell-cell interaction in maintaining beta-cell function.

Basic education, experience and skills required for consideration:
  • A Ph.D. degree in life or biomedical sciences, or a related discipline is required;
  • Strong interest in diabetes research/regenerative biology;
  • Extensive experience with basic molecular biology skills;
  • Experience with tissue collection, histology and immunohistochemistry;
  • Experience with cell culture, immunofluorescence, flow cytometry, and cell-sorting;
  • Strong work ethic;
  • Excellent written and verbal communication skills. Evidence of productivity reflected in first author publications in peer-reviewed journals;
  • Good problem solving skills and passion to follow relevant literature;
  • Ability to conduct independent research, and work effectively in a team.

Preferred education experience and skills:
  • Ph.D. in Molecular, Cellular or Developmental Biology;
  • Experience in handling animal models preferred;
  • Experience with epigenetic techniques preferred.

Additional Information:
  • To apply, please complete our online application, and include a cover letter stating your research interests and experience along with an updated CV and three references.
  • For more information about Dr. Shih's research, please click here .

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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