Dr. Wenquan Zou, in the Departments of Pathology and Neurology at the Case Western Reserve University School of Medicine, Cleveland, Ohio, is seeking outstanding candidates for a postdoctoral fellow position. Successful candidates must hold a PhD or an equivalent degree in biomedicine or related studies with background in molecular and cellular biology. A successful candidate must have hands-on experience in E.coli recombinant protein production. Other research experience in mouse models, primary cell cultures, protein folding, biochemistry, molecular and cellular biology, imaging and other related fields will also be helpful.
The Zou laboratory aims to elucidate the pathogenesis and early diagnosis of neurodegenerative diseases that are all associated with abnormal protein misfolding including, but not limited to, prion diseases, Parkinson’s disease and Alzheimer’s disease. Currently, the lab is studying prion disease, Parkinson’s disease, and Alzheimer’s disease, with a wide range of approaches, from in vitro biochemical studies with human tissues, cultured cells, and recombinant proteins to in vivo transmission study with animal models.
The interested candidates can check our recent publications in this area to understand the area of research better:
- Wang Z, Yuan J, Shen P, Abskharon R, Lang Y, Dang J, Adornato A, Xu L, Chen J, Feng J, Moudjou M, Kitamoto T, Langeveld J, Appleby B, Ma J, Kong Q, Petersen RB, Zou WQ, Cui L. In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation. Mol Neurobiol. 2019 Jan 5. doi: 10.1007/s12035-018-1459-0.
- Orrú CD, Yuan J, Appleby BS, Li B, Li Y, Winner D, Wang Z, Zhan YA, Rodgers M, Rarick J, Wyza RE, Joshi T, Wang GX, Cohen ML, Zhang S, Groveman BR, Petersen RB, Ironside JW, Quiñones-Mateu ME, Safar JG, Kong Q, Caughey B, Zou WQ. Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease. Sci Transl Med. 2017 Nov 22;9(417). pii: eaam7785. doi: 10.1126/scitranslmed.aam7785.
- Abskharon R, Dang J, Elfarash A, Wang Z, Shen P, Zou LS, Hassan S, Wang F, Fujioka H, Steyaert J, Mulaj M, Surewicz WK, Castilla J, Wohlkonig A, Zou WQ. Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors. Microb Cell Fact. 2017 Oct 4;16(1):170. doi: 10.1186/s12934-017-0782-x.
- Yuan J, Zhan YA, Abskharon R, Xiao X, Martinez MC, Zhou X, Kneale G, Mikol J, Lehmann S, Surewicz WK, Castilla J, Steyaert J, Zhang S, Kong Q, Petersen RB, Wohlkonig A, Zou WQ. Recombinant human prion protein inhibits prion propagation in vitro. Sci Rep. 2013 Oct 9;3:2911. doi: 10.1038/srep02911.