A postdoc position is immediately available at Case Western Reserve University in the structural biology lab of Dr. Focco van den Akker. The successful candidate will use structural biology and other approaches to uncover new therapeutic opportunities for developing antibiotics targeting the bacterial cell wall machinery. Bacterial proteins of interest are beta-lactamases, penicillin binding proteins, lytic transglycosylases, and others. For additional information, please see recent publications (Papp-Wallace et al. J. Med. Chem. 2018 10, 61, 4067-; Vijayaraghavan et al. PLoS One. 2018, 13, e0197136; van den Akker & Bonomo, 2018 Front. Microbiol., 9, 622) or the group website (https://case.edu/med/biochemistry/faculty/vandenakker.html).
This position is funded by NIH and other sources. This project is highly collaborative involving academic collaborators, several pharmaceutical companies, and clinician-researchers. In addition to protein crystallography, the project involves enzymatic structure-function studies, biophysical characterization for compound screening/testing, and drug design efforts.
Applications are solicited from highly motivated and creative individuals who can drive this multifaceted project. The applicant should have a Ph.D. and experience in either molecular biology or protein biochemistry (experience in protein crystallography and/or medicinal chemistry is not required but is desirable).
The position is open immediately and salary will be commensurate with qualifications and experience. Please send cover letter, CV, and contact information for three references to: firstname.lastname@example.org
Focco van den Akker, Ph.D.
Department of Biochemistry/RT500
Case Western Reserve University
10900 Euclid Avenue
Cleveland, OH 44106
The Case Western Reserve University is an Equal Opportunity/Affirmative Action employer.