Postdoctoral Research Fellow

Beth Israel Deadoness Medical Center & Harvard Medical School
Boston, Massachusetts (US)
December 20 2018
Organization Type

The Parikh laboratory at Harvard Medical School and Beth Israel Deaconess Medical Center in Boston is seeking a Postdoctoral Fellow who will lead a wholly NIH-funded project to understand the molecular processes regulating homeostasis of NAD+. NAD+ regulation in metabolically active organs may be pivotal both for cell-autonomous functions during acute stress and for generalized physiological disturbances such as impaired organ function. The successful applicant will apply systematic functional screens (e.g., CRISPR) to identify central control mechanisms for NAD+ balance and will lead vertically integrated experiments to evaluate metabolism and physiology across cellular and in vivo models of acute stress.

Candidates must be enthusiastic, passionate and self-motivated with a commitment to career development. You will have the support of an organized Departmental Postdoctoral training program including opportunities to present your work and bi-annual review of a personalized Individual Development Plan with your primary mentor and a co-mentor to ensure that you are meeting career goals. The candidate must be able to independently and efficiently manage concurrent projects and while possessing a strong commitment to contributing intellectually and interpersonally toward a positive and stimulating lab environment.

Essential Responsibilities

  1. Abides by the institutional policies of BIDMC relating to health and safety, equality of opportunity and data storage and management.
  2. As a member of the research team, actively pursues research under the supervision of a principal investigator while developing skills for independent work.
  3. Receives training in and performs duties contributing to the investigational work of the team including formulation of research questions and design, conduct of experiments, and evaluation of results.
  4. Prepares and publishes scientific manuscripts under direction of PI.
  5. Develops expertise in desired lab skills/informatics/ physics/clinical research. Develops proficiency with research tools and equipment. Develops ability to work with more independence as the fellowship progresses.

Required Qualifications:

  1. Doctoral degree required.
  2. 0-1 years related work experience required.
  3. Extensive experience in molecular biology, mammalian cell culture, manipulation of DNA and RNA in cells using CRISPR and RNAi.
  4. Ability to produce complex documents, perform analysis and maintain databases. Prior experience reviewing, analyzing, and summarizing scientific literature.
  5. Excellent attention to detail and interpersonal, organizational, writing, and project management skills.
  6. Strong organizational and data management skills.
  7. Advanced technical computer skills as required for technical support specific to functional area and related systems.


  1. Decision Making: Ability to make decisions that are guided by general instructions and practices requiring some interpretation. May make recommendations for solving problems of moderate complexity and importance.
  2. Problem Solving: Ability to address problems that are varied, requiring analysis or interpretation of the situation using direct observation, knowledge and skills based on general precedents.
  3. Independence of Action: Ability to follow precedents and procedures. May set priorities and organize work within general guidelines. Seeks assistance when confronted with difficult and/or unpredictable situations. Work progress is monitored by supervisor/manager.
  4. Written Communications: Ability to summarize and communicate in English moderately complex information in varied written formats to internal and external customers.
  5. Oral Communications: Ability to comprehend and communicate complex verbal information in English to medical center staff, patients, families and external customers.
  6. Knowledge: Ability to demonstrate in-depth knowledge of concepts, practices and policies with the ability to use them in complex varied situations.
  7. Team Work: Ability to lead collaborative teams for larger projects or groups both internal and external to the Medical Center and across functional areas. Results have implications for the management and operations of multiple areas of the organization.
  8. Customer Service: Ability to provide a high level of customer service and staff training to meet customer service standards and expectations for the assigned unit(s). Resolves service issues in the assigned unit(s) in a timely and respectful manner.

Physical Nature of the Job:

  1. Light work: Exerting up to 20 pounds of force frequently to move objects. Some elements of the job are sedentary, but the employee will be required to stand for periods of time or move throughout the hospital campus

To apply:
Interested applicants should send a single PDF file including:

  1. Cover letter (please state how you heard about the position)
  2. CV demonstrating publication of impactful work
  3. One-page statement of research interests
  4. Contact information for three references


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