Postdoctoral Fellow - T-cell Therapy for Viral Diseases & Solid Tumors

Location
Menlo Park, California
Salary
DOE
Posted
December 10 2018
Position Type
Full Time
Organization Type
Non-Profit

Postdoctoral Fellow – T-cell Therapy for Viral Diseases and Solid Tumors

Cell-based Medicine

 

We are seeking enthusiastic scientists to work in the Biosciences Division of SRI International. Candidates will bring contemporary approaches in T-cell immunology, such as genetically engineering primary T cells with chimeric antigen receptor (CAR T cells), immunological assays, and be motivated to contribute intellectually in a dynamic team environment.

We have transformed the T cell into a vector for synthesizing calibrated amounts of engineered proteins in vivo (see NIH Science Highlight, T-cell biofactories find, fight disease in one fell swoop; and publication in Advanced Biosystems, 2018), which may be reprogrammed to target biomarkers on different disease cells, e.g. cancer, viral infections, autoimmune disorders. The T-cell Biofactory may lead to a “living drug” that will extravasate to the disease sites, assess the disease burden, synthesize calibrated amount of engineered therapeutic proteins upon stimulation by the diseased cells, and reduce targeting of normal cells.

Successful candidates will reprogram primary T cells into T-cell Biofactories for targeting viral infections and solid tumors; and quantify their therapeutic responses when stimulated by the target cells. Candidates will choose among different target diseases including HIV, dengue, chikungunya, ovarian cancer, pancreatic cancer etc. Experience in in vivo viral infection or cancer models will be a plus. Candidates will write scientific publications and have the opportunity participate in the preparation of grant applications.

Requirements:

Recent PhD in immunology, virology, cancer biology or related field is required. Experience in CAR T cells will be a plus. Candidates are expected to have excellent communication, writing, organizational skills; and be motivated to contribute intellectually in a dynamic team environment. Successful candidates will be independent self-starters with experience and knowledge of contemporary approaches in immunology. Additionally, they will have the ability to design and execute laboratory experiments, critically interpret experimental results, and to present the data in a clear and concise manner.  Note: This position is located in the San Francisco Bay Area (Menlo Park, CA), and includes full benefits plus relocation assistance.

About SRI:

SRI Biosciences, a division of SRI International, integrates basic biomedical research with drug and diagnostics discovery and preclinical and clinical development. SRI International, an independent research center headquartered in Menlo Park, California, creates world-changing solutions to make people safer, healthier, and more productive.

How to apply:

Submit CV and cover letter outlining interests and accomplishments via www.sri.com/careers to job number 1972BR.

For additional information:

Contact Parijat Bhatnagar, PhD, Program Director, Cell-based Medicine, SRI International, Menlo Park, California, USA. Please reference the Science Careers posting.

SRI International is committed to hiring and retaining a diverse workforce. We are proud to be an Equal Opportunity/Affirmative Action Employer, making decisions without regard to race, color, religion, creed, sex, sexual orientation, gender identity, marital status, national origin, age, veteran status, disability, or any other protected class.

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