Post Doctoral Research Scientist
Postdoctoral Research Scientist at the MRI VA Hunter Holmes McGuire, VCU
We wish to recruit a highly motivated Postdoctoral Research Scientist to investigate mechanisms of cancer rejection with cell based immune mechanisms. The work will focus on understanding the cellular and molecular basis of non TCR dependent pathways of immune cell and tumor/stem cell cross talk. As we know the T cell function is regulated by co-inhibitory and co-stimulatory receptors. This has been harnessed into development of immune checkpoint therapies like the use of blocking antibodies targeting co-inhibitory receptors such as PD1 and CTLA4. This has opened a new doorway for cancer treatment, but the goal of cure is still elusive as, only a proportion of patients with a subset of cancers respond to this treatment. There is a need for development of further therapies in this field.
The successful applicant will join the laboratory of Dr. Syed Ammer Shah within McGuire Research Institute/VA. We will be focusing on targeting co-stimulatory receptors on T cells with cognate ligands on corresponding tumors and cancer stem cells to mechanistically understand the tenets associated with tumor regression and T cell survival in context of these pathways of cellular cross talk.
Candidates should have a PhD or MD/PhD, a good understanding of immunology and technical experience in cellular immunology, molecular biology and preferably murine immunology. Applicant should be proficient in cell culture techniques, western blots, qPCR, FACS analysis, viral transductions and gene knockdown with CRISPR/CAS system. The applicant will benefit from the collaborative research environment of other leading research institute members with expertise in tumor immunology as well as cancer and cancer stem cell biology. Employment will be through the McGuire Research Institute.
Please submit a copy of your CV and letter of intent with a brief outline of your research experience.