Cryo-EM Postdoctoral Associate
The Hormel Institute, a biomedical research center of the University of Minnesota, was established in 1942 and has an excellent reputation and long history for producing world-class medical research.
We are seeking highly motivated candidates specializing in Cryo-Electron Microscopy (Cryo-EM) to join the Cellular and Molecular Biology lab of Dr. Zigang Dong. The goal of this position will be to elucidate how intracellular membrane trafficking and remodeling processes, such as apoptosis and autophagy, are controlled and how dysregulation of these pathways may lead to cancer. The main focus is structure determination of multiprotein complexes using cryo-EM and single particle 3D reconstruction. The new state-of-the-art cryo-EM facility at the Hormel Institute is equipped with a FEI Titan Krios with phase plates and a direct electron detector. There is also a FEI Tecnai BT and an IBM cluster for image processing. The successful candidate will work on a project focused on the role of BAR protein endophilin B1 in the regulation of autophagy and apoptosis.
A Ph.D. or MD in Structural Biology, Biochemistry or a related field is required along with experience in protein purification, crystal structures, and/or cryo-EM. The candidate must demonstrate effective verbal and written communication skills and be able to work in a team of scientists from different backgrounds.