Research Scientist-Pharmaceutical Product Development

Employer
Lilly
Location
Indiana
Salary
Competitive
Posted
October 30 2018
Ref
42326BR
Discipline
Life Sciences
Position Type
Full Time
Organization Type
Pharma
Job Type
Other
Responsibilities
Do you have the passion, curiosity and creativity as well as have the discipline to get results and follow established fundamental processes? Do you have a basic understanding of drug development? If you have experience in design and development of pharmaceutical products using standard and novel delivery platforms please consider this opportunity. We are looking for a strong teammate with outstanding communication skills to work with other partners and collaborators.
The Small Molecule Design and Development (SMDD) Organization within the Lilly Research Labs is an integrated drug development organization which spans early discovery to submission and post-approval. The Translational Pharmaceutics group within SMDD has functional components that encompass selection of high quality drug molecules to enter development, design and development of the molecular physical properties, the drug product for pre-clinical and early clinical development and prototype commercial drug products for both small molecule and peptide assets.
You should have a strong background in formulation development of drug products using standard and novel oral delivery platforms. Additional background in non-oral delivery platforms is highly desirable. In this role, you will be able to integrate biopharmaceutics and human-centered design aspects to guide development of drug products for rapid clinical testing, and drug product prototypes for commercialization. The position requires laboratory experimentation work and ability to represent SMDD on program teams, operating comfortably in a dynamic, multi-disciplinary team environment. Also essential will be the ability to collaborate and communicate effectively with key partners within the company and in the external network.
As a Formulation Development Scientist you will have the opportunity to:
  • Determine performance criteria based on the traits of the disease and patient profile, taking into account the physicochemical and biopharmaceutical characteristics of the compound.
  • Translates the desired patient and in vivo performance requirements into drug product design criteria and consequently critical quality attributes.
  • Designs, develops and prototypes formulations for small molecules and peptides for oral and non-oral administration, integrating critical quality attributes with commercially viable manufacturing platforms, standards and business needs, and meeting the essential criteria for clinical testing and commercial development.
  • Keeps abreast of current literature and technology in the field and applies it to formulation development activities in a manner that improves the value of the molecule and translates it into an effective medicine for patients.
  • Communicates opportunities and risks to management to enable sound business decisions.
  • Identifies and appropriately applies available tools and technologies to guide design and development and effectively utilizes them to deliver step changes in drug delivery technologies and product development to improve the value of our portfolio.
  • Enhances Lilly's professional image and competitive advantage through patents, presentations, publications and professional activities.
  • Identifies and supports technical, productivity, and other initiatives, and influences key technical partners to maintain alignment.
  • Ensures individual and departmental compliance with the laws, regulations, guidelines, procedures, and practices governing drug research and development, including the departmental and corporate standard operating, good scientific, and safety procedures.

Company Overview
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Basic Qualifications
  • Bachelor's degree with 10 years of relevant experience or
  • M.S. degree with 8 years of relevant experience or
  • Ph.D. with relevant academic or industry experience
  • Experience in the design and development of formulations for small molecules and peptides for oral and non-oral administration, using standard and novel delivery platforms strongly preferred

Additional Skills/Preferences
  • Understanding of pre-formulation and analytical aspects of drug product design and testing, and able to perform preliminary analytical work relating to drug development
  • Understanding of biopharmaceutics/pharmacokinetic principles and drug product/process design factors impacting in vivo performance of drug products.
  • Basic understanding of regulatory aspects pertaining to clinical testing of drug products.

Additional Information
  • Limited travel may be required
  • Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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