Postdoctoral Fellow - Mitochondrial Metabolism in Cancer

October 18 2018
Life Sciences
Position Type
Full Time
Organization Type
About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

Requisition ID: 14907

Job Title: Postdoctoral Fellow Mitochondrial Metabolism in Cancer

Position Summary and Key Responsibilities:

The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow. Dr. Lei Jiang's laboratory investigates the contribution of metabolic alterations to the development of cancer and diabetes. His previous study identified a novel NADPH shuttle system supporting ROS defense in the anchorage independent cancer cells (Jiang L, et al. Nature, 2016). The mass spec based stable isotope (NOT radioactive) tracing has been a great tool in the cancer metabolism field, with the advantage of directly studying metabolism in patients (Hensley CT, et al. Cell, 2016). These studies provided additional knowledge to the well-known Warburg Effect. In addition to generate ATP for energy requirement, metabolism also provides building blocks and controls stress defense. Not only glycolysis, TCA cycle, amino acid and nuclide acid metabolism are all very active in both cultured cancer cells and patient tumors.

Dr. Jiang's lab focuses on the molecular mechanisms regulating central carbon metabolism (citrate) and signaling amino acid (serine) during the development and progress of metabolic diseases. The application of mathematical bioengineering based modeling prediction and experimental mass spec based metabolic tracing will provide a better understanding of the metabolic rewiring in diabetes, cancer and other diseases.

A motivated postdoc is encouraged to join Dr. Jiang's laboratory, which is a new addition to the Diabetes & Metabolism Research Institute, headed by Arthur D. Riggs, Ph.D., a pioneer in the field renowned for his work on synthesizing the first man-made gene and using synthetic genes to produce human insulin.

For more information about Dr. Jiang's research, please click here.

Please include a cover letter, updated CV, and three references with your application.

Minimum Education and Skills Required for Consideration:

  • A Ph.D. degree in life or biomedical sciences, or a related discipline is required;
  • Determined and self-motivated scientist;
  • 3 years or less postdoc experience;
  • Good publication record in metabolism, cancer or diabetes;
  • Excellent in written and verbal communication;
  • Good knowledge in statistics;
  • Excellent in computer skills.

Preferred Education and Skills:

  • PhD in biochemistry, molecular and cellular biology.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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