Postdoctoral Fellow

Rockville, Maryland
Salary according to NIH postdoctoral payscale.
October 15 2018
Position Type
Full Time
Organization Type

NIH-funded postdoctoral position available at the University of Maryland Institute for Bioscience and Biotechnology Research (IBBR) for biochemist/molecular biologist with recent PhD to join a multidisciplinary team investigating the structural basis for pathogen and tumor cell recognition by the human immune system. Several classes of recognition molecules are under study: antibodies, T cell receptors (TCRs), natural killer (NK) cell receptors, and variable lymphocyte receptors (VLRs). Projects include structural and biophysical studies of: 1) autoimmune and virus-specific TCRs, 2) NK receptor recognition of cellular and viral ligands, 3) TCR–CD3 complex, 4) evolution of adaptive immunity, and 5) structure-based design of hepatitis C vaccine. [Nat. Struct. Mol. Biol. 16, 725-730 (2009); EMBO J. 30, 1137-1148 (2011); PNAS 109, 5405-5410 (2012); PNAS 109, 14960-14965 (2012); PNAS 110, 11505-11510 (2013); Annu. Rev. Biophys. 42, 191-215 (2013); J. Biol. Chem. 290, 10117-10125 (2015); PNAS 113, E6946-E6954 (2016); Cell Rep. 19, 569-583 (2017); J. Biol. Chem. 293, 15991-16005 (2018)]. Visit Experience in heterologous protein expression in bacterial or eukaryotic cells and in SPR/AUC/ITC highly desirable. Excellent opportunities for collaborative studies with X-ray crystallographers and NMR spectroscopists. IBBR, a joint research center of the University of Maryland and the National Institute of Standards and Technology (NIST), is located in the heart of a major biotech community that includes MedImmune and GlaxoSmithKline. Send CV and names of three references to Dr. Roy A. Mariuzza (

The University of Maryland is an Equal Opportunity Employer.

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