Sr./Scientist, Preclinical Pharmacology, Autoimmunity

Employer
Moderna
Location
Massachusetts
Salary
Competitive
Posted
October 01 2018
Organization Type
Biotech
Sr./Scientist, Preclinical Pharmacology, Autoimmunity

The Role:
An opportunity for a preclinical pharmacologist is available to join Moderna's early discovery and innovation incubator, New Venture Labs. New Venture Labs utilizes multidisciplinary approaches to understand protein structure, molecular signaling pathways, and dynamics of novel targets in preparation for their advancement into our drug discovery pipeline. Basic and applied research areas of interest include the immunopathology of autoimmune disorders, the MOA of tolerance induction, for example, regulatory dendritic cell (DC) and regulatory T cell biology, and expertise in preclinical disease models.

Here's What You'll Do:

Specific projects will involve collaborative interactions in a multidisciplinary group and across diverse biology areas that target proteins and pathways in DC and T cell biology. This is a basic research position that requires critical thinking, flexibility, multitasking, and the ability to learn new techniques.

Responsibilities:

  • Design and execution of well-controlled in vivo and in vitro experiments to demonstrate proof-of-concept in pre-clinical models of autoimmunity, and further develop deep mechanistic understanding of tolerogenesis
  • In-depth characterization of cellular and humoral immune responses in various mouse models of autoimmunity and humoral immunity.
  • Develop, execute, and trouble-shoot assays, including in vitro differentiation of mouse/human dendritic and T cell subsets for in vitro assays, flow cytometry, ELISA, and microscopy.
  • Manage collaborative relationships with project leads, key internal and external stakeholders, and the Moderna research leadership to resource and advance portfolio projects.
  • Share and contribute scientific and technical know-how and experience with team members.
  • Clearly analyze, communicate, and present scientific findings to senior management and teams to influence decision making from Immunology perspective

Here's What You'll Bring to the Table:

  • Ph.D. in immunology with 3 or more years spent overseeing the interaction of the immune system in the autoimmunity, transplantation, and inflammatory diseases (in vivo models).
  • Strong level of understanding and expertise in either one or more of the following: in vivo models for mechanistic understanding of our drug candidates and preclinical disease models in autoimmunity, inflammatory diseases, and transplantation,
  • Deep experience in single cell transcriptome analysis and inmmunophenotyping is highly preferred
  • Demonstrated ability to design and execute new experimental approaches
  • Publication of original scientific work in high-quality journals
  • 3 years of independent research experience in the pharmaceutical or biotech industry will be a plus
  • Candidate will be curious in exploring new path for drug discovery, bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes
  • Excellent team spirit, communication and presentation skills

Here's What We'll Bring to the Table:

  • Daily on-site catered lunches.
  • Company-provided iPhone.
  • Free parking, monthly subway pass or a subsidized commuter rail pass.
  • Highly competitive healthcare coverage. Including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP.
  • Flexible Spending Accounts for medical expenses and dependent care expenses.
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately.
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays.
  • Adoption assistance, competitive parental leave, discount to local childcare centers, as well as access to Care.com

Why join Moderna Therapeutics

We are pioneering a new class of medicines made of messenger RNA, or mRNA. The potential implications of using mRNA as a drug are significant and far-reaching. It could transform not only how certain diseases are treated but also how medicines are discovered, developed and manufactured - at a breadth, scale and speed not common in the biopharma industry. 

Since our founding in 2011, we have built the industry's leading mRNA technology platform, the infrastructure to accelerate drug discovery and speed early development, a rapidly expanding pipeline, and an unparalleled team. Our development pipeline includes development candidates for mRNA-based vaccines and therapies spanning several therapeutic areas, and we have multiple clinical trials already underway with other development candidates progressing toward the clinic. In addition, we have a number of discovery programs that are advancing toward the development stage. 

We invite you to explore our site to learn more about our company and how we are advancing the promise of mRNA science to improve health and impact lives around the world. 

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

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Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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