Director of Research x 3

Cambridgeshire (GB)
£71,404 Grade 12
September 21 2018
Position Type
Full Time
Organization Type

Director of Research x 3

Department/Location: MRC Toxicology Unit, Cambridge

Salary: £71,404 Grade 12

Reference: PU16742

Director of Research x 3

- Epigenetics

- Immunology

- Computational Biology

The MRC Toxicology Unit is a leading International Research Institute within the School of Biological Sciences, University of Cambridge. The Unit delivers high impact mechanistic toxicology research, pursuing hypothesis-driven toxicological questions with a particular focus on the study of the causal links between exposure to endogenous and exogenous toxicants, molecular initiating events and adverse outcome pathways.  The Unit's overall aims are to carry out pioneering research which leads to improved health and to train and mentor the next generation of toxicologists. Our research environment provides state-of-the-art research facilities including microscopy, Cryo-EM, flow cytometry, proteomics, bioinformatics and imaging.  In addition, excellent opportunities exist for collaborative interactions with University of Cambridge researchers.

We are looking to appoint Directors of Research across three research themes: Gene-environment interactions following Toxic Exposure; Computational and Systems Biology; and Inflammatory responses and Immune Regulation.  We are particularly interested in those with a strong research record in the following areas:

- Epigenetics: determining how the DNA or RNA epigenome changes following exposure to pharmaceuticals/environmental agents, studies directed at obtaining mechanistic information about of the mode of action and physiological consequences of these epigenetic changes.

- Immunology: studying the adverse effects on the immune system resulting from therapeutic exposure to biologics, including immune modulators and CAR- T cells, adverse immune responses to chemicals and environmental agents including respiratory tract allergies, allergic contact dermatitis or autoimmunity.

- Computational Biology: carrying out in silico modelling studies, and/or experimental work, to generate new algorithms to predict toxicity of established and novel compounds.

As Director of Research you will develop the scientific strategy for your research programme and contribute to the strategic direction of the Unit.  Leading a team of researchers and students you will contribute to the advancement of knowledge in your research subject, maintain an exceptionally successful programme of funding; collaborate externally and internally to advance thinking and disseminate your research in international papers and at international conferences.

Applicants must have a PhD and an international reputation within their field; they will have led original research in a relevant area and be able to build effective and sustainable international collaborative partnerships.  They will have the vision, experience and enthusiasm to build on current strengths within the Unit as well as an established track record in attracting research grant support. 

We offer a generous support package; including competitive salary, core-funded postdoctoral posts and PhD studentships.

These posts are open-ended contracts funded by the Medical Research Council. 

For further details about the MRC Toxicology Unit visit:

Please ensure that you upload a covering letter, CV and contact details of your referees with your application.

Closing date: 31st October 2018

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

Informal enquiries are invited and can be directed to Anne Willis at

If you have any queries regarding the application process please contact Rebecca Heatherley at

Please quote reference PU16742 on your application and in any correspondence about this vacancy.

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