Postdoctoral Positions Membrane remodeling in muscle function and myopathy

Location
San Diego, California
Salary
Salary commensurate with NIH pay scale up to 2-5 years with excellent benefits.
Posted
September 18 2018
Ref
Membrane biology in muscle function and myopathy
Position Type
Full Time
Organization Type
Academia

Postdoctoral Positions
Membrane remodeling in muscle function and myopathy

Two NIH-funded postdoctoral positions are immediately available to study cellular and molecular mechanisms of muscle T-tubule membrane organization and remodeling. Emphasis is on the underlying membrane trafficking and its genetic regulation involved in maintaining muscle function and the cellular basis in fly models of human myopathy.

Research opportunities build on our published and unpublished studies, including novel genetic screen results in Drosophila muscles, that address factors involved in shaping and remodeling T-tubule membranes critical for muscle function (see Ribeiro et al. 2011 PLoS Genetics; Fujita et al. 2017 eLife). Specific efforts explore endocytic and autophagic mechanisms involved in regulated disassembly and reassembly of T-tubule membranes during developmental and adult muscle remodeling programs.

Applicants must have a Ph.D. (or plans to complete in near future) in cell-developmental biology or a related field. Ideal candidates are highly motivated and engaged researchers with expertise in at least several of these disciplines: membrane biology/trafficking, muscle biology, microscopy imaging, tissue dissections, Drosophila genetics, molecular biology and/or biochemistry. Of particular interest are applicants familiar with or strongly interested in animal studies that combine modern genetic modification methods with advanced live cell microscopy imaging techniques. The muscle membrane projects have parallels to additional research in the lab in other fly tissues and human cells on the regulation of phosphoinositide functions, endolysosomal trafficking and autophagy. Postdoctoral candidates broadly interested in these other areas of membrane biology research are also encouraged to apply.

Successful candidates will join a dynamic research environment within the UCSD Division of Biological Sciences, with access to many additional scientific benefits and life/career opportunities in the broader San Diego research community.

Interested candidates should email Dr. Amy Kiger (akiger@ucsd.edu) to apply, including (1) a cover letter that summarizes previous research experiences and how applicant's interests fit with the lab projects, (2) CV with complete publication list, and (3) upon request, three letters of references.

UC San Diego is an equal opportunity/affirmative action employer with a strong institutional commitment to the achievement of diversity.

Amy Kiger, Associate Professor
Division of Biological Sciences, UC San Diego
Natural Science Building Room 6109
9500 Gilman Drive MC 0380
La Jolla, CA 92093-0380

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