Postdoctoral Research Position
I am seeking a motivated, independent, creative entry level post-doctoral researcher to join my laboratory at the University of Colorado School of Medicine. My lab is interested in understanding the molecular mechanism of pre-mRNA splicing and its role in disease processes, including cancer, as well as developing potential therapeutic approaches targeting splicing in these processes. We use a combination of structural (cryoEM and crystallography), biochemical, genetic, molecular biology, and cell biology approaches. Below are two examples of our recent publications:
CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Nat Commun. 2017; 8:1035. PMID 29051543.
Structure of the yeast spliceosomal postcatalytic P complex. Science. 2017; 358:1278-1283. PMID 29146870.
The postdoc candidate can choose to focus on any one or more of the following projects depending on his/her interest and expertise:
Structural studies of spliceosome and related proteins/RNAs using cryoEM and crystallography;
Functional studies of spliceosomal proteins or RNAs and splicing mechanism using molecular biology, biochemistry, and high throughput sequencing;
The role of a splicing factor in Myc-driven cancer and drug discovery targeting the splicing factor.
My lab is located on the University of Colorado Denver Anschutz Medical Campus within the highly collegial Department of Biochemistry and Molecular Genetics and is part of the RNA BioScience Initiative. Denver is a great place to live and to do research. To apply, please send an email with a cover letter summarizing past research accomplishments, research interest, long term plans, and start date availability; CV; and contact information of three references to Rui.Zhao@ucdenver.edu.